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Adverse effects of β-agonists

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1 Adverse effects of β-agonists
Malcolm R. Sears, MB  Journal of Allergy and Clinical Immunology  Volume 110, Issue 6, Pages S322-S328 (December 2002) DOI: /mai Copyright © 2002 Mosby, Inc. Terms and Conditions

2 Fig. 1 Regular inhaled albuterol increased allergen-induced late response manifested by a greater fall in FEV1. (From Gauvreau GM, Jordana M, Watson RM, et al. Effect of regular inhaled albuterol on allergen-induced late responses and sputum eosinophils in asthmatic subjects. Am J Respir Crit Care Med 1997;156: With permission.) Journal of Allergy and Clinical Immunology  , S322-S328DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

3 Fig. 2 Regular inhaled albuterol increased sputum eosinophils, ECP, and EG2-positive cells (activated eosinophils). (From Gauvreau GM, Jordana M, Watson RM, et al. Effect of regular inhaled albuterol on allergen-induced late responses and sputum eosinophils in asthmatic subjects. Am J Respir Crit Care Med 1997;156: With permission.) Journal of Allergy and Clinical Immunology  , S322-S328DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

4 Fig. 3 Effect of βAR polymorphisms on response to β2-agonists. A deleterious effect of regular albuterol was seen only in subjects with Arg/Arg polymorphisms at codon 16. AM PEF, Morning peak expiratory flow. (From Israel E, Drazen JM, Liggett SB, et al. The effect of polymorphisms of the β2-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med 2000;162: With permission.) Journal of Allergy and Clinical Immunology  , S322-S328DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions


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