1. Inflammation of small airways in asthma
Qutayba Hamid, MD, PhDa, Yunling Song, MDa, Thomas C. Kotsimbos, MDa, Eleanor Minshall, PhDa, Tony R. Bai, MDb, Richard G. Hegele, MDb, James C. Hogg, MD, PhDb 
Journal of Allergy and Clinical Immunology 
Volume 100, Issue 1, Pages (July 1997)
DOI: /S (97)
Copyright © 1997 Mosby, Inc. Terms and Conditions

2. Fig. 1
Representative examples of immunocytochemical identification of T cells (CD3) (A) and MBP-positive eosinophils (B) in airways greater than 2 mm in diameter from patients with asthma. C, Example of MBP immunostaining of an airway greater than 2 mm in diameter from a nonasthmatic subject. D, Example of EG2-positive cells (activated eosinophils) in an airway less than 2 mm in diameter. Note the large number of activated eosinophils present. E, Example of T-cell immunostaining in asthmatic airways less than 2 mm in diameter. F, Example of eosinophil MBP immunostaining in lung parenchyma tissue from a patient with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

3. Fig. 1
Representative examples of immunocytochemical identification of T cells (CD3) (A) and MBP-positive eosinophils (B) in airways greater than 2 mm in diameter from patients with asthma. C, Example of MBP immunostaining of an airway greater than 2 mm in diameter from a nonasthmatic subject. D, Example of EG2-positive cells (activated eosinophils) in an airway less than 2 mm in diameter. Note the large number of activated eosinophils present. E, Example of T-cell immunostaining in asthmatic airways less than 2 mm in diameter. F, Example of eosinophil MBP immunostaining in lung parenchyma tissue from a patient with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

4. Fig. 1
Representative examples of immunocytochemical identification of T cells (CD3) (A) and MBP-positive eosinophils (B) in airways greater than 2 mm in diameter from patients with asthma. C, Example of MBP immunostaining of an airway greater than 2 mm in diameter from a nonasthmatic subject. D, Example of EG2-positive cells (activated eosinophils) in an airway less than 2 mm in diameter. Note the large number of activated eosinophils present. E, Example of T-cell immunostaining in asthmatic airways less than 2 mm in diameter. F, Example of eosinophil MBP immunostaining in lung parenchyma tissue from a patient with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

5. Fig. 1
Representative examples of immunocytochemical identification of T cells (CD3) (A) and MBP-positive eosinophils (B) in airways greater than 2 mm in diameter from patients with asthma. C, Example of MBP immunostaining of an airway greater than 2 mm in diameter from a nonasthmatic subject. D, Example of EG2-positive cells (activated eosinophils) in an airway less than 2 mm in diameter. Note the large number of activated eosinophils present. E, Example of T-cell immunostaining in asthmatic airways less than 2 mm in diameter. F, Example of eosinophil MBP immunostaining in lung parenchyma tissue from a patient with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

6. Fig. 1
Representative examples of immunocytochemical identification of T cells (CD3) (A) and MBP-positive eosinophils (B) in airways greater than 2 mm in diameter from patients with asthma. C, Example of MBP immunostaining of an airway greater than 2 mm in diameter from a nonasthmatic subject. D, Example of EG2-positive cells (activated eosinophils) in an airway less than 2 mm in diameter. Note the large number of activated eosinophils present. E, Example of T-cell immunostaining in asthmatic airways less than 2 mm in diameter. F, Example of eosinophil MBP immunostaining in lung parenchyma tissue from a patient with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

7. Fig. 1
Representative examples of immunocytochemical identification of T cells (CD3) (A) and MBP-positive eosinophils (B) in airways greater than 2 mm in diameter from patients with asthma. C, Example of MBP immunostaining of an airway greater than 2 mm in diameter from a nonasthmatic subject. D, Example of EG2-positive cells (activated eosinophils) in an airway less than 2 mm in diameter. Note the large number of activated eosinophils present. E, Example of T-cell immunostaining in asthmatic airways less than 2 mm in diameter. F, Example of eosinophil MBP immunostaining in lung parenchyma tissue from a patient with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

8. Fig. 2
Immunocytochemical cell markers in airways less than 2 mm in diameter (A) and airways greater than 2 mm in diameter from patients with asthma (B) and control subjects. T cells (CD3), total eosinophils (MBP), activated eosinophils (EG2), and mast cells (tryptase) were studied. Values given are average data of six (<2 mm) or 10 (>2 mm) airways from four to six patients with asthma and 13 (<2 mm) or 31 (>2 mm) airways from six to 10 nonasthmatic control subjects. A, Patients with asthma; C, control subjects.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

9. Fig. 2
Immunocytochemical cell markers in airways less than 2 mm in diameter (A) and airways greater than 2 mm in diameter from patients with asthma (B) and control subjects. T cells (CD3), total eosinophils (MBP), activated eosinophils (EG2), and mast cells (tryptase) were studied. Values given are average data of six (<2 mm) or 10 (>2 mm) airways from four to six patients with asthma and 13 (<2 mm) or 31 (>2 mm) airways from six to 10 nonasthmatic control subjects. A, Patients with asthma; C, control subjects.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

10. Fig. 3
Immunocytochemical cell markers in airways less than 2 mm and greater than 2 mm in diameter from patients with asthma. T cells (CD3), total eosinophils (MBP), activated eosinophils (EG2), and mast cells (tryptase) were examined. For airways with a Pi of less than 2 mm, values given are means of six airways from four patients with asthma; for airways with a Pi of greater than 2 mm, values given are means of 10 airways from six patients with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

11. Fig. 4
Schematic diagram showing tissue area between epithelial layer and smooth muscle layer (A1) and between smooth muscle layer and adjacent parenchyma (A2).
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

12. Fig. 5
Distribution of T cells (CD3), total eosinophils (MBP), activated eosinophils (EG2), and mast cells (tryptase) in A1 (internal layer) and A2 (external layer) in the airways of patients with asthma. Values given are means of 10 airways from six patients with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

13. Fig. 5
Distribution of T cells (CD3), total eosinophils (MBP), activated eosinophils (EG2), and mast cells (tryptase) in A1 (internal layer) and A2 (external layer) in the airways of patients with asthma. Values given are means of 10 airways from six patients with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

14. Fig. 5
Distribution of T cells (CD3), total eosinophils (MBP), activated eosinophils (EG2), and mast cells (tryptase) in A1 (internal layer) and A2 (external layer) in the airways of patients with asthma. Values given are means of 10 airways from six patients with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions

15. Fig. 5
Distribution of T cells (CD3), total eosinophils (MBP), activated eosinophils (EG2), and mast cells (tryptase) in A1 (internal layer) and A2 (external layer) in the airways of patients with asthma. Values given are means of 10 airways from six patients with asthma.
Journal of Allergy and Clinical Immunology  , 44-51DOI: ( /S (97) )
Copyright © 1997 Mosby, Inc. Terms and Conditions