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Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,

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Presentation on theme: "Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,"— Presentation transcript:

1 Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta, MSc, Susanne Lau, MD, PhD, Petra Wagner, Renate L. Bergmann, MD, Sabina Illi, PhD, Karl E. Bergmann, MD, Thomas Keil, MD, MSc, Stephanie Hofmaier, Alexander Rohrbach, Carl Peter Bauer, MD, Ute Hoffman, MD, Johannes Forster, MD, Fred Zepp, MD, Antje Schuster, MD, Ulrich Wahn, MD, Paolo Maria Matricardi, MD  Journal of Allergy and Clinical Immunology  Volume 130, Issue 4, Pages e5 (October 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 IgE to P pratense by time from onset of grass-related seasonal allergic rhinitis. A, Bars show the prevalence of IgE sensitization (≥0.35 kUA/L) to P pratense (extract) in children whose sera were available at each point in time. The number of tested children is indicated over each bar. B, Bars show the geometric mean levels of IgE antibodies to P pratense (extract) at each point in time in IgE antibody–positive sera. The numbers of tested children is indicated over each bar. Lines show the average number of all 8 (triangles) or only 7 (squares; Phl p 6 excluded) allergenic molecules of P pratense recognized by IgE antibodies at each point in time in IgE antibody–positive sera. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 IgE to P pratense allergenic molecules from the onset of grass-related seasonal allergic rhinitis. Lines show the prevalence of IgE sensitization (ISAC class ≥1) to the 8 P pratense allergenic molecules in children whose sera were available at each time point. The number of children examined at each time point is indicated under the x-axis. Clinical stages of seasonal allergic rhinitis are also indicated. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Probability of remaining free of sensitization to individual allergenic molecules of P pratense. Kaplan-Meier plots of the probability of remaining free of IgE sensitization to each of 8 allergenic molecules of P pratense are shown. The number of the subjects at risk is shown below the x-axis. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E1 Probability of remaining free of seasonal allergic rhinitis related to grass pollen. Kaplan-Meier plots of the probability of remaining free of seasonal allergic rhinitis related to grass pollen among 820 children participating in the MAS birth cohort are shown. The number of subjects at risk is shown below the x-axis. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E2 Probability of remaining free of seasonal allergic rhinitis related to grass pollen at age 3 years by IgE sensitization to P pratense (extract). Kaplan-Meier plots of the probability to remain free of seasonal allergic rhinitis related to grass pollen stratified by IgE sensitization to grass pollen at age 3 years are shown. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E3 Probability of remaining free of seasonal allergic rhinitis related to grass pollen by IgE sensitization to P pratense (extract). Kaplan-Meier plots of the probability at 6 years of age of remaining free of seasonal allergic rhinitis related to grass pollen stratified by IgE sensitization to grass pollen are shown. The number of subjects examined at each follow-up point is reported under the x-axis. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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