Add value for laboratory automation LABWORKS LIMS Implementation Team

Experience from South Africa Agenda Case Studies Ergon Vertellus INEOS …… European customers Experience from South Africa PerkinElmer LABWORKS™ LIMS for Biodiesel Production

Investing in LABWORKS benefits processing laboratories Faster, more reliable data benefits the entire organization by allowing quicker sample turnaround, more accurate data and efficient reporting. Integration with ERP and plant operation systems Automated reporting and notifications Quality - Eliminate redundant data transcriptions Instrument Interfaces save time and eliminate costly errors We’ll look at how Ergon Refining Inc.’s Specialty Products Plant in Vicksburg, MS implemented LABWORKS LIMS to improve lab and plant operations.

Ergon At Ergon's specialty refinery in Vicksburg, Mississippi, wax-free naphthenic crude oils are processed to produce distinctive specialty petroleum and asphalt products for niche markets worldwide. Special processing technology, developed exclusively by Ergon’s hydroprocessing pilot plant, allows safe, efficient and clean refining of high-acid, high-sulfur crude oils. The hydroprocessing unit, where the naphthenic base oils are produced, is the largest single-train naphthenic base oil processing unit in the world.

Automatically log in sample taken on regular basis Ergon Mapping of unit stream, finished product, tanks, shipment and certificate of analysis Automatically log in sample taken on regular basis Bar code system to avoid entries GC result integration Complicated calculation Approval steps

Interface capabilities Ergon Interface capabilities SimDis to optimize product yield: Labworks accept information such as temperature at which component come off distillation stream and keep it Comunication with the PI real time performance management platform Interface to blending system: tank certification and shipment data

Ergon Decision drivers: decision made because Labworks configurability enabled the client to meet the complete requirements of a large refinery – without expensive consultants or customization. automating previously manual operations and integrating with several software packages.

Concerns: what will a LIMS Implementation Do For Me? Can I get my data to all the areas in the enterprise it needs to go? Can an “out-of-the-box” LIMS possibly meet all our laboratory and enterprise needs? I hear it takes forever to implement a LIMS – Do I have the time and enough manpower to get through it

Concerns with implementing a LIMS Can I get my data to all the areas in the enterprise it needs to go? LABWORKS has interfaced virtually all major enterprise control systems, reporting systems and instruments. Ergon interfaced LABWORKS with both SimDist and their plant operation system. This allowed their data to cross unit boundaries to track overall refinery operations. They also gained auditing and security that was lacking in the past. Custom Certificate of Analysis reporting ties together product test results to shipments. Ergon is certified ISO9001:2000.

Investing in LABWORKS benefits processing laboratories Real time data tracking

Investing in LABWORKS benefits processing laboratories Management by Exception

Instant Access to information

Implementing a LIMS Can an “out-of-the-box” LIMS can possibly meet all our laboratory and enterprise needs? LABWORKS is one of the most configurable LIMS available today, enabling it to meet the needs of large refineries without expensive customization Ergon uses LABWORKS Process Scheduler, to automatically login regular samples. LABWORKS’ calculation utility automates their calculations saving time and increasing accuracy. Interfaces to different instruments eliminate manual data entry and provide permanent record of important process information.

Concerns with implementing a LIMS Do I have the time and enough manpower to get through it? Proven Return on Investment metrics from LABWORKS more than justify the time spent implementing a LIMS. no custom programming minimal implementation efforts business processes improvement The end result: 20% increase in samples (to about 40,000/year) No added staff. Data entry and calculation reductions substantially improved data accuracy as well.

SAP Integration, PI Integration H1: INEOS USA LLC Ineos Styrenics We operate a world-scale production plant, which is the largest production facility in the Midwest distribution area – where the majority of US polystyrene demand is located LIMS Replacement SAP Integration, PI Integration quality control process improvement: lab and production are connected in real time 20% increase in samples without additional staff members Data accuracy improvement Time 60 Days Ineos specified a five concurrent user system utilizing Microsoft SQL Server and various options including Certificate of Analysis and Report Designer modules as well as an SAP interface to accommodate free inspection points. Project Description: Implementation was accomplished in 90 days, including the conversion of existing data and development of an SAP interface. LABWORKS has saved Ineos significant time at aver stage of the quality control process. Data entry is so much faster than Ineos old system and is considered a key factor in this client’s ability to handle a 20% increase in samples without additional staff members. With vastly reduced data entry and an automated calculation bonus, data accuracy is on the rise. Ineos Corporation, Chanahan, IL - LIMS Replacement Project Planning / Management Install/ Training SAP Integration, PI Integration Complete Data Migration Time 60 Days Innovene (Whiting, IN) - LIMS Replacement Vertellus Corp, Indianapolis - LIMS Replacement System IQ/OQ 90 Days

Complete Data Migration Time 60 Days H1: INEOS / INNOVENE Innovene Innovene has more than $12bn of total assets, 40 billion pounds of petrochemicals production capacity and $15bn of revenues Innovene, now part of the INEOS Group, is a truly global company, employing more than 8,000 people worldwide at 30 office and manufacturing sites (including joint ventures): 3 in Asia, 13 in Europe and 14 in North America. LIMS Replacement Complete Data Migration Time 60 Days Ineos Corporation, Chanahan, IL - LIMS Replacement Project Planning / Management Install/ Training SAP Integration, PI Integration Complete Data Migration Time 60 Days Innovene (Whiting, IN) - LIMS Replacement Vertellus Corp, Indianapolis - LIMS Replacement System IQ/OQ 90 Days

VERTELLUS SPECIALTIES INC Vertellus, based in Indianapolis, Indiana, is a specialty chemicals company focused on the manufacture of high growth, high-value products sold to the agricultural, nutritional, pharmaceutical, personal care and performance materials markets. Vertellus was created by the combination of Reilly Industries and Rutherford Chemicals, two portfolio companies currently owned by Arsenal Capital Partners Agriculture & Nutrition Specialties ("Agriculture & Nutrition") is a leading manufacturer of pyridine, picolines and vitamin B-3, serving the agricultural chemicals and nutrition markets. Health & Specialty Products ("Health & Specialty") has a large portfolio of high-value specialty chemicals that are primarily used in the pharmaceutical and personal care markets.   Performance Materials is a leading manufacturer of castor and citrate polymer additives and systems that are used in plastics, adhesives, coatings, sealants and personal care applications Ineos Corporation, Chanahan, IL - LIMS Replacement Project Planning / Management Install/ Training SAP Integration, PI Integration Complete Data Migration Time 60 Days Innovene (Whiting, IN) - LIMS Replacement Vertellus Corp, Indianapolis - LIMS Replacement System IQ/OQ 90 Days

How a LIMS will benefit your operation Interfaces to your plant operating systems will help your laboratory data meet the end-user quickly and efficiently You will save time by eliminating redundant, repetitive tasks Calculations can be performed automatically, saving time and reducing errors Improved accuracy and efficiency in reporting

Chemical Ethyl Corporation manufactures and distributes diesel cetane improver and gasoline performance additives throughout North America.  Ethyl also provides terminal storage and distribution services from its Texas and Holland facilities.  Ethyl has a significant interest in the tetraethyl lead (TEL) business. Ethyl maintains operations in Richmond, Virginia; Houston, Texas; Sarnia, Ontario, Canada; Brussels, Belgium; and Dordrecht, Holland. Client: Ethyl Corporation Address: 1000 North South Avenue Pasadena, TX 77503 Number of Users: 5 users Database: Microsoft Access® Modules: Laser Barcode and Barcoding and Labeling, Monthly Operating Report, Statistical Analysis, Process Scheduler, Report Designer, Laboratory Personnel Training, and Certificate of Analysis. Project Description: PerkinElmer implemented LABWORKS™ LIMS at Ethyl in 2003. Project services included installation, configuration, and user training. PerkinElmer continues to provide on-going software support services and regular software updates.

BIG WEST OF CALIFORNIA Big West of California LLC, Bakersfield Refinery 66,000 Barrels per day Big West of California primarily markets finished motor fuel products in the Bakersfield and Fresno areas. The refinery is also a large supplier of gas oil products to other refiners.

BIG WEST OIL LLC Big West Oil LLC is a wholly owned subsidiary of Flying J Inc. Big West operates a 31,000 barrel per day refinery located in North Salt Lake, Utah. The refinery processes crude oils produced in Utah, Wyoming, Colorado, and Canada. Big West produces a full range of petroleum products including gasoline, diesel, liquid petroleum gases, wax products, and fuel oil. These products are marketed in Utah, Southern Idaho, Western Wyoming, Western Colorado, and Eastern Nevada

SNAM RETE GAS (Italy) http://www.snamretegas.it/english/chi_siamo/societa.htm Manages the natural gas transportation network in Italy 80 billion cubic meters of gas a year: third biggest European market Highly sophisticated control room equipped with the most advanced instrumentation to control quality and quantity of gas Labworks is the key to automate Instruments interface Project: live in 10 days

Minister of Health: Virology department (Kuwait) Virology Lab in Kuwait Automate the flow to discover virus Patient ID Sample Result: there is, there is not Interface to instrument: Axsym from Abbot BAP3 from Boehringer DNA Analyzer Chiron system 340 LIMs has been package with instrument order (Liquid handling) Project: live

GRUPO BETA (Spain) Ponemos a su disposición una amplia variedad de soluciones de calidad para tratamientos del agua. Drink Water plant control Instrument Optima 2100 GCMS with hs trap Lambda25 with as93 Spectrum bx Microwave 3000 HPLC LIMS has been packaged with instrument order (240k euro) Project: live Project: 15 days

Administration de la gestion de l’eau (Luxembourg) Coordination of the governmental action in the interest of a durable management and protection of the natural resources of water Coordination and orientation of measurements necessary to the food of the drinking water country The protection of the collected resources, with the purification of urban and industrial waste water, with installation, the maintenance and improvement of the non navigable and non floatable rivers After complaints for missing support, we started to be close to them and now is a good reference for us in Europe

JRC (Italy) Environmental http://www.jrc.cec.eu.int/ "The mission of the JRC is to provide customer-driven scientific and technical support for the conception, development, implementation and monitoring of EU policies. As a service of the European Commission, the JRC functions as a reference centre of science and technology for the Union. Close to the policy-making process, it serves the common interest of the Member States, while being independent of special interests, whether private or national.“ Project: on going

ST microelectronics: Lab-on-chip (Italy) From the world’s foremost microfluidic supplier comes a powerful new molecular diagnostics tool for DNA amplification and analysis. ST’s In-Check™ lab-on-chip brings the exponential power of the Polymerase Chain Reaction (PCR) into a cost effective and convenient format. Clinicians no longer need to compromise between sensitivity, specificity and speed. http://www.st.com/stonline/products/technologies/labonchip/labonchip.htm semiconductor competition: ABI Project: on going Buffer/chip Do test and do other test based on results Workflow definition

Aminothec AS (Norway) End 2005 deal: 100k Splitting fish protein into free amino acid by using enzymatic methods Production plant Finished product and raw material control LIMS has been considered as strategic tool to create the lab within a new plant Future integration of the ERP system Go live planned end of September Project: 80%

Experiences from South Africa: Stephen Varthy

PKI Biodiesel