PLATELET RICH PLASMA (PRP) TREATMENT

INTRODUCTION  Platelet Rich Plasma (PRP) is cutting edge therapy in the field of cosmetic enhancements.  Although the procedure is relatively new,PRP has been recognized as an effective treatment in sports injury, diabetic ulcer treatment, and orthopedics to name a few.  Now patients who wish to use their own body’s regenerative power can do so without the concerns for infection, foreign material, or surgical interventions.

PLATELET RICH PLASMA (PRP)  Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains several different growth factors and other cytokines that stimulate healing of bone and soft tissue.blood plasmaplateletsautologousgrowth factorscytokinessoft tissue

PLATELET RICH PLASMA  What is PRP?  Human blood is comprised primarily of red blood cells (RBC), as well as white blood cells (WBC), platelets, and plasma.  By initiating the first step of coagulation, platelets are the key to the body’s ability to heal wounds.  It is thought that by increasing the platelet count in a wounded area, the body’s healing to that area would be accelerated – explaining the use of PRP (platelet rich plasma) in wound healing.  Platelet rich plasma is concentrated blood plasma which contains approximately five times the number of platelets found in normal circulating blood. In addition, blood plasma contains the growth factors PDGF and VEGF and other bioactive proteins that aid in wound healing.

PREPARATION  There are, at present, two methods of PRP preparation approved by US FDA. [3 [3  ] Both processes involve the collection of whole blood that is anticoagulated with citrate dextrose) before undergoing two stages of centrifugation designed to separate the PRP aliquot from platelet-poor plasma and red blood cells. [ ]whole bloodanticoagulatedcitrate dextrosecentrifugationplatelet-poor plasmared blood cells [  3] In humans, the typical baseline blood platelet count is approximately 200,000 per µL; therapeutic PRP concentrates the platelets by roughly five-fold. [[6][7] 3]µL [[6][7]

COMPOSITION OF BLOOD R.B.C- 93% W.B.C- 1% PLATELETS AND activation Growth Factor release accelerared tissue and wound healing.

PREPARATION  PRP can easily be seperated from blood, through a process of CENTRIFUGATION  Using your enriched plasma permits the body to heal faster and more efficiently  because your plasma (autologous) is used there is no danger of disease transmission or allergic reaction.

BASIS PRP  The basis of PRP lies in decreasing RBC count to 5% since they are less useful in healing process while increasing platelet count to 94%  PRP or blood plasma is the source of concentrated platelet content present in the blood.

USES OF PRP MEDICAL USES 1. Acceleration of healing of tendon injuries 2. osteoarthritis treatment 3. jaw reconstruction 4. cardiovascular medicine. 5. The concentrated form of plasma has been shown to accelerate wound healing and tissue repair and, thus, could potentially benefit hair restoration procedures 6. In hair transplantation, PRP can be injected into the recipient site area to theoretically stimulate the healing of the transplanted grafts and into the donor area to facilitate healing of the donor incision. 7. Scar treatment

PRP AND HAIR  Growth factors in PRP when released promote 1 Tissue repair 2 Angiogenesis (capillary formation) 3 Capillary production 4 Normalisation of hair follicular unit 5 PRP can reverse miniaturisation process of hair follicles 6 Wake up dormant follicular stem cells

RESULT AFTER 2 SITTINGS OF PRP

PRP AND FUE  Follicular unit transplantation outcomes may be increased by the correct application of PRP.  Donor site pre-treatment with PRP ( purpose is to provide platelet cell therapy and platelet-derived growth factors, both of which are key elements in wound healing).  Recipient site pre-treatment with PRP ( this seems to be an important factor affecting graft growth and survival rates).  Optimal use of intra-operative PRP and platelet-derived growth factors, in and around the graft  Graft emersion in PRP ( “ soaking the graft in the PRP gel”)

PRP AND FUE  Following advantages are claimed by use of PRP  to enhance donor site wound healing  to decrease the incidence of infection  to reduce donor scarring  to increase donor scar tensile strength  to enhance recipient site healing (which should increase growth)  to be utilized as an effective treatment protocol in severe cases of wound dehiscence or infection.

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