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Published byMarilynn Preston Modified over 9 years ago
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Mr Basim Matti FRCS London Dr Peter Everts PhD Eindhoven, Holland
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Mr Matti 31 Patients Data Set as of 1 st November 2011
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PRP PRP is an autologous blood product with a high concentration of platelets. The platelets produce a cocktail of Cytokines and Growth Factors, which trigger and accelerate the regeneration of tissues.
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PRP It is concentration of human platelets in a small volume of plasma measured > than 1,000,000 platelets /mm³ = 4-6x the normal Normal value of platelet concentration in whole blood 150,000-400,000mm³
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Aim Of PRP Therapy Regeneration of collagen and Elastine fibres Prevention of collagen degradations Rejuvenation of the skin
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Wound healing principles Wound healing principles
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Platelet physiology
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Platelet activation
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Growth Factors
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Platelet Rich Plasma Concentration of Growth Factors PDGR – 130 times Platelet derived Growth Factor TGF beta – 80 times Transforming Growth Factor-beta. VEGF – 11 times Vascular Endothelial Growth Factor IGF 1 Insulin like Growth Factor, HGF Hepatocyte GF, Basic Fibroplasten GF
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How Growth Factor Works
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Areas for injection Injection sites into dermal layer and dermal junction
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Source: Seishin Institute Japan >12,000 patients undergone PRP Therapy “NEW PRP Skin Regeneration Therapy, three to five times richer in platelets than conventional PRP therapy inject platelet-rich plasma containing white blood cells. “ http://www.saiseiiryou.com Seishin Institute Japan. Hyaluronic Acid PRP
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Cytomedix Angel System Enclosed Point of Care System
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Automatic collection of PRP
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Peripheral blood Platelet level 276.000mm³ Dense Platelet concentration 2.750.000mm ³ using Angel™ System
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Other Test Tube systems
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Our PRP Technique 52ml blood draw 8mls citrate ACD-A Angel processing 18 minutes PRP yield 2mls highly concentrated average 12.2 x baseline platelets Add 4mls platelet poor plasma = 6mls PRP injected with platelet concentration >850.000mm³ >3-4 x baseline platelet concentration
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Video: Procedure 56secs www.youtube/avancemedical/final_edit_5th_November
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Our Experience: Cohort n31
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8 wks Post Pre
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Source: Sclafani A.P. (2010) Platelet Rich Fibrin Matrix for improvement of deep naso-labial folds. Journal of Cosmetic Dermatology, Vol.9: 66-71
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Sclafani A.P. (2011) Safety, Efficacy and Utility of Platelet Rich Fibrin Matrix ARCH Facial Plastic Surgery Published on line Feb 2011 doi:10.1001/archfacial.2011.3 Sclafani A.P. (2009) Applications of Platelet Rich Safety, Fibrin Matrix in Facial Plastic Surgery Facial Plastic Surgery Vol 25 No. 4
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Patient Questionnaire Key questions: Improvement in tone of skin Improvement in texture of skin Reduction in lines Improved ‘glow’ or radiance of the skin Volumetric improvement ????
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PATIENT SURVEY Respondents 21 patients Respondents 21 patients 19% (4 patients) see no difference 81% (17 patients) see and feel a difference in skin tone and texture. 42.86% (9 patients) state they see a marked improvement in skin tone, texture and reduction of lines. 38.1% (8 patients) extremely satisfied with the results.
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Age Distribution
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Further Research Number & intervals of treatments Longevity of treatment Combination therapies Micro needling Mesotherapy Ultrasound Cost of treatment Is it worth it?
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barbados meating THANK YOU
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Thank you
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