1. Bone Morphogenetic Protein By: Kim Stephens

2. What is Bone Morphogenetic Protein? Stimulates a patient's own cells to induce the formation of bone and cartilage  Recombinant human bone morphogenetic protein-2, or rhBMP-2 Generates and repairs bone faster and more reliably Latest in bone growth enhancement

3. Changing Points 1965: Dr. Marshall Urist, UCLA Department of Orthopedic Surgery in Los Angeles, CA discovered that the proteins needed to heal bone was inside bones 1997: First clinical trial with 11 patients 2001: New Hampshire Spine Institute

4. Applications Available in an oral form A supplement for bone and joint health Regenerative Medicine: Delivered to the site of the fracture Released gradually to allow bone formation Delivery in a purified collagen matrix

5. Potential Applications  Osteoinductive characteristics make BMPs valuable as an alternative to bone grafts  Other methods of delivering BMPs to patients are undergoing evaluation  Non-skeletal tissues  Organogenesis

6. Advantages Less pain, shorter hospital stays More rapid return to a normal life As effective as bone grafts Eliminate the need for bone transplantation Avoids the potential side effects and complications of bone harvesting or grafts Disadvantages BMP has only been FDA approved for one type of spinal fusion Expensive Side effects are not fully understood

7. Future  Use of BMP will potentially extend beyond skeletal disease and injury  Approval from the FDA to use BMP’s for dental work  Better understand these proteins and their benefits

8. Works cited  http://www.spineuniverse.com/treatments/surgery/spina l-fusion-bone-morphogenetic-protein http://www.spineuniverse.com/treatments/surgery/spina l-fusion-bone-morphogenetic-protein  http://www.spineuniverse.com/exams-tests/bone- morphogenetic-protein-bmp http://www.spineuniverse.com/exams-tests/bone- morphogenetic-protein-bmp  http://www.medscape.com/viewarticle/446738_3 http://www.medscape.com/viewarticle/446738_3  http://www.zycalbio.com/research.htm http://www.zycalbio.com/research.htm  http://en.wikipedia.org/wiki/Bone_morphogenetic_prote in http://en.wikipedia.org/wiki/Bone_morphogenetic_prote in  http://www.spine-health.com/treatment/spinal- fusion/bmp-bone-morphogenetic-proteins http://www.spine-health.com/treatment/spinal- fusion/bmp-bone-morphogenetic-proteins  http://www.freepatentsonline.com/4294753.html http://www.freepatentsonline.com/4294753.html  http://webapps.css.udel.edu/biotech/rDNA.html http://webapps.css.udel.edu/biotech/rDNA.html  http://www.sciencedirect.com/science/article/pii/S0006 291X07017147 http://www.sciencedirect.com/science/article/pii/S0006 291X07017147