3. What is REGENERATIVE MEDICINE? “The regeneration or replacement of cells, tissues or organs to restore or establish normal function.” The goal is to help you live a more normal life.

4. Under investigational protocols, the physicians of the KRMC offer the latest in PRP and Adult Stem Cell treatments. These new modalities may be the answer you are looking for…

5. What is PRP? PRP is made from a patient’s blood Centrifugation removes the red cells leaving behind plasma with a concentration of platelets These products contain growth factors – special proteins that aide wound healing

6. What are Stem Cells? Stem cells are found throughout your body They have 3 main jobs: – Keeping the immune system in check – Replacing tissues that are lost in day-to-day life – Coordinating repair of injuries

7. What conditions are being treated? Orthopedic conditions – Arthritis, osteonecrosis, non-healing fractures etc. Immune-mediated diseases – Multiple Sclerosis (MS), chronic-obstructive pulmonary disease (COPD) etc. Critical limb ischemia Many other diseases are being investigated…

8. Evidence for Osteoarthritis Nathan et al, Tis Eng, 2003, 9(4) “Biomechanically, the repair tissue approximated intact cartilage”

9. Evidence for Osteoarthritis “Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function.” “All clinical results significantly improved at 2-year follow- up” Koh et al, Knee Surg Sports Traumatol Arthrosc, 2013 Dec (epub)

10. Evidence for Osteonecrosis Adipose stem cells AND PRP injected into femoral head of patients with severe osteonecrosis… “presence of sustained,regenerated medullary bone-like tissue in 2 severely necrotic femoral heads.” Pak, J. Pain Physician, 2012; 15

11. Clinical Study - Fractures J Bone Joint Sx (1998) 80:985-996

12. Case Study - Fractures J Bone Joint Sx (1998) 80:985-996 Comparison in Fracture – Implant without Stem Cells

13. Case Study - Fractures J Bone Joint Sx (1998) 80:985-996 Comparison in Fracture – Implant with Stem Cells

14. Critical Limb Ischemia #1 Cause of Amputation Miranville et al, Circulation 2004;110; 349-355

15. Ischemic Limb - #1 Cause of Amputation Das et al, World J Surgery, 2013; 37(4) All were confirmed as no-option patients by a vascular surgeon After a single injection of stem cells, 86% of the limbs treated with stem cells were saved! “Mesenchymal stem cells for critical limb ischemia are safe and efficacious”

16. Safety Stem cells are collected by liposuction – 1000’s are performed daily in the US For PRP all that is required is blood Both these products come from your own body, there is no chance for rejection

17. Safety “MSCs [stem cells] have been used in clinical trials since 1995; currently, more than 80 trials are registered with ClinicalTrials.gov and no significant adverse events have been reported.” Sensebe et al, Mesenchymal stem cells for clinical applications, Vox Sanguinis, 2010; 98

18. Safety “this study with 100 joint injections of ADSCs, in the form of SVF, with PRP shows that ADSCs/PRP treatment is safe and provides long-term pain improvement” Pak et al, Safety reporting on implantation of autologous adipose tissue- derived stem cells with platelet-rich plasma into human articular joints, BMC Musculoskeletal Disorders, 2013; 14

19. Think you may be a candidate? www.kansasRMC.com 785-320-4700