Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9):724-735.

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Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Recommended sequence of diagnostic testing in patients who are at average risk for surgical complications, according to pretest probability and the results of computed tomography (CT).topbottomThe recommended sequence of tests when CT results are possibly malignant ( ) and when CT results are benign ( ) is shown. Subsequent test selection is shown to be a function of pretest probability and the corresponding post-test probability once the results of CT are known. Note that surgery is preferred when positron emission tomography (PET) results are positive, biopsy is preferred when PET results are negative, and watchful waiting is preferred when biopsy results are nondiagnostic. Recommendations are based on the assumption that society is willing to pay $ per quality-adjusted life-year gained. Results were very similar when willingness to pay was assumed to be $ or $ per quality-adjusted life-year gained. FDG-PET = positron emission tomography with 18-fluorodeoxyglucose. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Suggested algorithm for clinical management of patients with solitary pulmonary nodules who are at average risk for surgical complications.CTThe algorithm pertains to patients with low (10% to 50%), intermediate (51% to 76%), and high (77% to 90%) pretest probability of malignancy. Note that in patients with very low pretest probability ( 90%), surgery without diagnostic testing is the preferred strategy. FDG-PET = positron emission tomography with 18-fluorodeoxyglucose. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Decision model.ACTFDG-PETBCD Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Decision model subtrees. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Markov model. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Observed and modeled survival for patients with local, regional, and distant lung cancer.SEER Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Distribution of tumor doubling times and corresponding probabilities of disease progression during the observation period.(20)black circles Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Summary receiver-operating characteristic (ROC) curve for positron emission tomography with 18-fluorodeoxyglucose (FDG-PET).dotted linesblack squareblack circle Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Summary receiver-operating characteristic (ROC) curve for computed tomography (CT).dotted lines Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Health care costs for patients with malignant pulmonary nodules.black circlesblack squaresblack triangles Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Recommended sequence of diagnostic testing in patients who are at average risk for surgical complications, according to pretest probability, computed tomography (CT) results, and threshold that determines cost- effectiveness.QALYPET Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/1/2016 From: Cost-Effectiveness of Alternative Management Strategies for Patients with Solitary Pulmonary Nodules Ann Intern Med. 2003;138(9): doi: / Recommended sequence of diagnostic testing in patients who are at high risk for surgical complications, according to pretest probability, computed tomography (CT) results, and threshold that determines cost- effectiveness.FDG-PETQALY Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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