1. Date of download: 5/28/2016 From: High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized Trial Ann Intern Med. 1994;120(5):375-381. doi:10.7326/0003-4819-120-5-199403010-00004 Flow chart representing the study design.Note that the experimental group did not receive acyclovir. Two approaches were used for the experimental group. First, antiviral prophylaxis was not used for patients who were not shedding virus. Second, preemptive ganciclovir therapy was used only if cytomegalovirus (CMV) shedding was observed. Buffy coat and urine cultures for CMV were done 2, 4, 6, 8, 12, 16, and 24 weeks after transplantation. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 5/28/2016 From: High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized Trial Ann Intern Med. 1994;120(5):375-381. doi:10.7326/0003-4819-120-5-199403010-00004 Cumulative probability (Kaplan-Meier curve) of a patient shedding cytomegalovirus where the end point is first viral isolation.nnThe probability of shedding cytomegalovirus was not statistically different between the acyclovir group ( = 24) and the experimental group ( = 23). Three patients died without viral shedding, one in the acyclovir group at about 5 weeks after transplantation and two in the experimental group, both at approximately 4 weeks after transplantation. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 5/28/2016 From: High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized Trial Ann Intern Med. 1994;120(5):375-381. doi:10.7326/0003-4819-120-5-199403010-00004 The frequency and timing of cytomegalovirus infection and disease in the two study groups.CMV = cytomegalovirus. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 5/28/2016 From: High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized Trial Ann Intern Med. 1994;120(5):375-381. doi:10.7326/0003-4819-120-5-199403010-00004 The cumulative probability (Kaplan-Meier curves) of cytomegalovirus disease in the acyclovir (n = 24) and experimental groups (n = 23).PThe probability of disease differed between the two groups ( = 0.03). Four patients died without any evidence of cytomegalovirus disease before the end of study, one in the acyclovir group at about 5 weeks after transplantation and three in the experimental group at 4, 4, and 10 weeks after transplantation. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians