1. Date of download: 6/3/2016 From: Chest Pain Relief by Nitroglycerin Does Not Predict Active Coronary Artery Disease Ann Intern Med. 2003;139(12):979-986. doi:10.7326/0003-4819-139-12-200312160-00007 Predictive value and likelihood ratios of chest pain relief by nitroglycerin for active coronary artery disease (CAD).Top.Bottom.leftrightThe sensitivity and specificity of chest pain relief by nitroglycerin for the presence of active CAD are low both in the overall study sample and in the prespecified subgroup analyses. The 95% CIs for both the positive ( ) and the negative ( ) likelihood ratios for the response of chest pain to nitroglycerin include 1.0, indicating that this test has no statistically significant diagnostic value in both the overall study sample and in the prespecified subgroup analyses. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 6/3/2016 From: Chest Pain Relief by Nitroglycerin Does Not Predict Active Coronary Artery Disease Ann Intern Med. 2003;139(12):979-986. doi:10.7326/0003-4819-139-12-200312160-00007 Receiver-operating characteristic curves for chest pain relief by nitroglycerin and active coronary artery disease.pain relieftopbottomtopbottomTwo series of sensitivities and specificities were calculated by varying the decrease in pain intensity defined as : Pain relief is considered as a percentage reduction in pain intensity ( ) and as an absolute reduction in pain intensity ( ). Both curves closely approximate a likelihood ratio of 1.0, indicating that, independent of cutoff, chest pain relief by nitroglycerin has no statistically significant diagnostic value. Representative points are labeled on the receiver-operating characteristic curves, including 50% and 100% pain reduction ( ) and 2.0-unit and 5.0-unit reduction ( ). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 6/3/2016 From: Chest Pain Relief by Nitroglycerin Does Not Predict Active Coronary Artery Disease Ann Intern Med. 2003;139(12):979-986. doi:10.7326/0003-4819-139-12-200312160-00007 Patient enrollment and study flowchart.CAD = coronary artery disease. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians