1. Tortora & Grabowski 9/e  2000 JWS 23-1 BIOLOGY 252 Human Anatomy & Physiology Chapter 23 The Respiratory System: Lecture Notes

2. The Respiratory System Cells continually use O 2 & release CO 2 Respiratory system designed for gas exchange Cardiovascular system transports gases in blood Failure of either system – rapid cell death from O 2 starvation

3. Respiratory System Anatomy Nose Pharynx = throat Larynx = voicebox Trachea = windpipe Bronchi = airways Lungs Locations of infections –upper respiratory tract is above vocal cords –lower respiratory tract is below vocal cords

4. Nose - Internal Structures Large chamber within the skull Roof is made up of ethmoid and floor is hard palate Internal nares (choanae) are openings to pharynx Nasal septum is composed of bone & cartilage Bony swelling or conchae on lateral walls

5. Functions of the Nasal Structures Olfactory epithelium for sense of smell Pseudostratified ciliated columnar with goblet cells lines nasal cavity –warms air due to high vascularity –mucous moistens air & traps dust –cilia move mucous towards pharynx Paranasal sinuses open into nasal cavity –found in ethmoid, sphenoid, frontal & maxillary –lighten skull & resonate voice

6. Pharynx Muscular tube (5 inch long) hanging from skull –skeletal muscle & mucous membrane Extends from internal nares to cricoid cartilage Functions –passageway for food and air –resonating chamber for speech production –tonsil (lymphatic tissue) in the walls protects entryway into body Distinct regions -- nasopharynx, oropharynx and laryngopharynx

7. Cartilages of the Larynx Thyroid cartilage forms Adam’s apple Epiglottis---leaf-shaped piece of elastic cartilage –during swallowing, larynx moves upward –epiglottis bends to cover glottis Cricoid cartilage---ring of cartilage attached to top of trachea Pair of arytenoid cartilages sit upon cricoid –many muscles responsible for their movement –partially buried in vocal folds (true vocal cords)

8. Larynx Cartilage & connective tissue tube Anterior to C4 to C6 Constructed of 3 single & 3 paired cartilages

9. Vocal Cords False vocal cords (ventricular folds) found above vocal folds (true vocal cords) True vocal cords attach to arytenoid cartilages

10. Trachea Size is 12 cm (5 in) long & 1in diameter Extends from larynx to T5 anterior to the esophagus and then splits into bronchi Layers –mucosa = pseudostratified columnar with cilia & goblet –submucosa = loose connective tissue & seromucous glands –hyaline cartilage = 16 to 20 incomplete rings open side facing esophagus contains trachealis m. (smooth) internal ridge on last ring called carina –adventitia binds it to other organs

11. Trachea and Bronchial Tree Full extent of airways is visible starting at the larynx and trachea

12. Histology of the Trachea Ciliated pseudostratified columnar epithelium Hyaline cartilage as C-shaped structure closed by trachealis muscle

13. Airway Epithelium Ciliated pseudostratified columnar epithelium with goblet cells produce a moving mass of mucus.

14. Tortora & Grabowski 9/e  2000 JWS 23-14 Tracheostomy and Intubation Tracheotomy, syn. = Tracheostomy Reestablishing airflow past an airway obstruction –crushing injury to larynx or chest –swelling that closes airway –vomit or foreign object Tracheostomy is incision in trachea below cricoid cartilage if larynx is obstructed Intubation is passing a tube from mouth or nose through larynx and trachea

15. Bronchi and Bronchioles Primary bronchi supply each lung Secondary bronchi supply each lobe of the lungs (3 right + 2 left) Tertiary bronchi supply each bronchopulmonary segment Repeated branchings called bronchioles form a bronchial tree

16. Tortora & Grabowski 9/e  2000 JWS 23-16 Tidal volume = amount air moved during quiet breathing MVR= minute ventilation is amount of air moved in a minute Reserve volumes ---- amount you can breathe either in or out above that amount of tidal volume Residual volume = 1200 mL permanently trapped air in system Vital capacity & total lung capacity are sums of the other volumes Lung Volumes and Capacities

17. Structures within a Lobule of Lung Branchings of single arteriole, venule & bronchiole are wrapped by elastic CT Respiratory bronchiole –simple squamous Alveolar ducts surrounded by alveolar sacs & alveoli –sac is 2 or more alveoli sharing a common opening

18. Photomicrograph of lung tissue showing bronchioles, alveoli and alveolar ducts. Histology of Lung Tissue

19. Cells Types of the Alveoli Type I alveolar cells –simple squamous cells where gas exchange occurs Type II alveolar cells (septal cells) –free surface has microvilli –secrete alveolar fluid containing surfactant Alveolar dust cells –wandering macrophages remove debris

20. Alveolar-Capillary Membrane Respiratory membrane = 1/2 micron thick Exchange of gas from alveoli to blood 4 Layers of membrane to cross –alveolar epithelial wall of type I cells –alveolar epithelial basement membrane –capillary basement membrane –endothelial cells of capillary Vast surface area = handball court

21. Details of Respiratory Membrane Find the 4 layers that comprise the respiratory membrane

22. Double Blood Supply to the Lungs Deoxygenated blood arrives through pulmonary trunk from the right ventricle Bronchial arteries branch off of the aorta to supply oxygenated blood to lung tissue Venous drainage returns all blood to heart

23. Breathing or Pulmonary Ventilation Air moves into lungs when pressure inside lungs is less than atmospheric pressure –How is this accomplished? Air moves out of the lungs when pressure inside lungs is greater than atmospheric pressure –How is this accomplished? Atmospheric pressure = 1 atm or 760mm Hg

24. Boyle’s Law As the size of closed container decreases, pressure inside is increased The molecules have less wall area to strike so the pressure on each inch of area increases.

25. Dimensions of the Chest Cavity Breathing in requires muscular activity & chest size changes Contraction of the diaphragm flattens the dome and increases the vertical dimension of the chest

26. Diaphragm moves 1 cm & ribs lifted by external intercostal muscles Intrathoracic pressure falls and 2-3 liters of air is inhaled Quiet Inspiration

27. Passive process with no muscle action Elastic recoil & surface tension in alveoli pulls inward Alveolar pressure increases & air is pushed out Quiet Expiration

28. Labored Breathing Forced expiration –abdominal mm force diaphragm up –internal intercostals depress ribs Forced inspiration –sternocleidomastoid, scalenes & pectoralis minor lift chest upwards as you gasp for air

29. Intrapleural Pressures (see text p. 885) & Intrathoracic pressures Always subatmospheric (756 mm Hg) As diaphragm contracts intrathoracic pressure decreases even more (754 mm Hg)

30. Alveolar Surface Tension Thin layer of fluid in alveoli causes inwardly directed force = surface tension –water molecules strongly attracted to each other Causes alveoli to remain as small as possible Detergent-like substance called surfactant produced by Type II alveolar cells –lowers alveolar surface tension –insufficient in premature babies so that alveoli collapse at end of each exhalation

31. Tortora & Grabowski 9/e  2000 JWS 23-31 Pneumothorax Pleural cavities are sealed cavities not open to the outside Injuries to the chest wall that let air enter the intrapleural space –causes a pneumothorax –collapsed lung on same side as injury –surface tension and recoil of elastic fibers causes the lung to collapse

32. Tortora & Grabowski 9/e  2000 JWS 23-32 Compliance of the Lungs Ease with which lungs & chest wall expand depends upon elasticity of lungs & surface tension Some diseases reduce compliance –tuberculosis forms scar tissue –pulmonary edema - fluid in lungs & reduced surfactant –paralysis

33. Airway Resistance Resistance to airflow depends upon airway size –increase size of chest airways increase in diameter –contract smooth muscles in airways decreases in diameter

34. Breathing Patterns Eupnea = normal quiet breathing (yu-p-ne a) Apnea = temporary cessation of breathing (ap ne a) Dyspnea =difficult or labored breathing (disp-ne a) Tachypnea = rapid breathing (tak-ip-ne a) Diaphragmatic breathing = descent of diaphragm causes stomach to bulge during inspiration Costal breathing = just rib activity involved

35. Modified Respiratory Movements Coughing –deep inspiration, closure of glottis & strong expiration blasts air out to clear respiratory passages Hiccuping –spasmodic contraction of diaphragm & quick closure of glottis produce sharp inspiratory sound Valsalva maneuver - forced exhalation against a closed glottis as may occur when lifting a heavy weight Chart of others on page 868

36. Tortora & Grabowski 9/e  2000 JWS 23-36 The Gas Laws Boyle’s Law – the pressure of a gas varies inversely with its volume (if temperature remains constant). Gay-Lussac’s Law – the pressure of a gas increases directly in proportion to its (absolute) temperature.

37. Tortora & Grabowski 9/e  2000 JWS 23-37 The Gas Laws Dalton’s Law – in a mixture of gasses, each gas exerts a partial pressure, proportional to its concentration. Henry’s Law – the quantity of a gas that will dissolve in a liquid is directly in proportional to its partial pressure, if temperature remains constant.

38. Tortora & Grabowski 9/e  2000 JWS 23-38 What is the Composition of Air? Air = 20.93% O2, 79.04% N2 and 0.03% CO2 Alveolar air = 14% O2, 79% N2 and 5.2% CO2 Expired air = 16% O2, 79% N2 and 4.5% CO2 –Anatomical dead space = 150 ml of 500 ml of tidal volume

39. Dalton’s Law In a mixture of gasses, each gas exerts a partial pressure, proportional to its concentration. Each gas in a mixture of gases exerts its own pressure as if all other gases were not present partial pressures denoted as p Total pressure is sum of all partial pressures atmospheric pressure (760 mm Hg) = pO 2 + pCO 2 + pN 2 + pH 2 O Thus in atmospheric air with a total pressure of 760 mm Hg, O 2 which makes up 20.93% - has a partial pressure of 20.93/100 x 760 = 159.1 mm Hg.

40. Henry’s Law The quantity of a gas that will dissolve in a liquid is directly proportional to its partial pressure, if temperature remains constant. OR The quantity of a gas that will dissolve in a liquid depends upon the amount of gas present and its solubility coefficient

41. Tortora & Grabowski 9/e  2000 JWS 23-41 Partial Pressures of Respiratory Gases at Sea Level Total100.00760.07607607060 H 2 O0.000.04747470 O 2 20.93159.11051004060 CO 2 0.030.24040466 N 2 79.04600.75685735730 Partial pressure (mmHg) % inDryAlveolarArterialVenousDiffusion Gasdry airairairbloodbloodgradient

42. Tortora & Grabowski 9/e  2000 JWS 23-42 The Processes of Respiration Pulmonary ventilation – or breathing, is the mechanical flow of air into (inhalation) and or out of (exhalation) the lungs External respiration – is the exchange of gases between the air spaces of the lungs and the blood in the pulmonary capillaries. In this process, pulmonary capillary blood gains O 2 and loses CO 2 Internal respiration – is the exchange of gases between blood in systemic capillaries and tissue cells. The blood loses O 2 and gains CO 2. Within cells, the metabolic reactions that consume O 2 and give off CO 2 during the production of ATP termed cellular respiration

43. External Respiration Gases diffuse from areas of high partial pressure to areas of low partial pressure Exchange of gas between air & blood Deoxygenated blood becomes saturated Compare gas movements in pulmonary capillaries to tissue capillaries

44. Rate of Diffusion of Gases Depends upon partial pressure of gases in air –p O 2 at sea level is 160 mm Hg –10,000 feet is 110 mm Hg / 50,000 feet is 18 mm Hg Large surface area of our alveoli Diffusion distance is very small (0.5 µm) Solubility & molecular weight of gases –O 2 smaller molecule diffuses somewhat faster –CO 2 dissolves 24x more easily in water so net outward diffusion of CO 2 is much faster

45. Internal Respiration Exchange of gases between blood & tissues Conversion of oxygenated blood into deoxygenated Observe diffusion of O 2 inward –at rest 25% of available O 2 enters cells –during exercise more O 2 is absorbed Observe diffusion of CO 2 outward

46. Oxygen Transport in the Blood Oxyhemoglobin contains 98.5% chemically combined oxygen and hemoglobin – inside red blood cells Does not dissolve easily in water –only 1.5% transported dissolved in blood (plasma)

47. Blood is almost fully saturated at pO 2 of 60mm –people OK at high altitudes & with some diseases Between 40 & 20 mm Hg, large amounts of O 2 are released as in areas of need like contracting muscle Hemoglobin and Oxygen Partial Pressure

48. Acidity & Oxygen Affinity for Hb As acidity increases, O 2 affinity for Hb decreases Bohr effect H+ binds to hemoglobin & alters it O 2 left behind in needy tissues

49. pCO2 & Oxygen Release As pCO 2 rises with exercise, O 2 is released more easily CO 2 converts to carbonic acid & becomes H+ and bicarbonate ions & lowers pH.

50. Temperature & Oxygen Release Metabolic activity & heat As temperature increases, more O 2 is released

51. Tortora & Grabowski 9/e  2000 JWS 23-51 Carbon Monoxide Poisoning CO from car exhaust & tobacco smoke Binds to the Hb heme group more successfully than O 2 CO poisoning Treat by administering pure O 2

52. Tortora & Grabowski 9/e  2000 JWS 23-52 Carbon Dioxide Transport 100 ml of blood carries 55 ml of CO 2 Is carried by the blood in 3 ways –dissolved in plasma –combined with the globin part of Hb molecule forming carbaminohemoglobin –as part of bicarbonate ion CO 2 + H 2 O combine to form carbonic acid (H 2 CO 3 ) that dissociates into hydrogen ions (H+) and bicarbonate ions (HCO 3 - )

53. Role of the Respiratory Center Respiratory mm. controlled by neurons in pons & medulla 3 groups of neurons –medullary rhythmicity –pneumotaxic –apneustic centers

54. Tortora & Grabowski 9/e  2000 JWS 23-54 CONDITIONS AT VARIOUS ALTITUDES