1. 1 Anatomy Review Heart Blood Vessels Blood

2. 2 Cardiovascular and Lymphatic Disease — Bacterial Septicemias Septicemia Lymphangitis Commonly Gram –ve Septic shock may be lethal 50-70% death rate

3. 3 BacterialCardiovascular and Lymphatic Disease Puerperal Fever (Childbirth fever) –________________________ –Poor asepsis after childbirth or abortion –Microbes enter uterus –Penicillin usually effective, slow recovery Group B Streptococcal Disease –_________________________ –Neonatal sepsis/ meningitis –Common in vaginal microflora, testing is recommended in 3 rd trimester

4. 4 Bacterial Systemic Disease — Plague Yersinia pestis ______________ – chipmunk borne in U.S.A. __________________ – rat borne Highly virulent –Phagocyte destruction –Complement degradation –Multiple entry routes –50- 60% mortality

5. 5 Plague Types ________________ –Blackish hemorrhages seen through skin –Grossly swollen lymph nodes –Antibiotics will cure, if D x is prompt _________________ –Microbes in blood –Meningitis, pneumonia, death _________________ –Invariably fatal in 1-3 days –Medical workers at risk Delta 32 CCR5 mutation

6. 6 Bacterial Systemic Disease — Tularemia Francisella tularensis –Rodent borne (esp. cotton tail rabbits) –Multiple entry routes –Symptoms –Microbes multiply in phagocytic cells –Antibiotics are effective

7. 7 Bacterial Systemic Disease — Lyme Disease Borrhelia burgdorferi –Tick borne –Flu-like symptoms –Bull’s eye rash Treatable with _____________ Failure to treat