Presentation on theme: "Spirochetes and Misc Bacteria Slackers Facts by Mike Ori."— Presentation transcript:
Spirochetes and Misc Bacteria Slackers Facts by Mike Ori
Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes. The document can mostly be used forward and backward. I tried to mark questionable stuff with (?). If you want it to look pretty, steal some crayons and go to town. Finally… If you’re a gunner, buck up and do your own work.
Describe the morphology and size of a spirochete
Spirochetes are long but very narrow spiral shaped bacterial with internal flagella that course down the side of the bacterium essentially between the inner and outer membrane,
Name the spirochete visualization technique
Usually best visualized with dark-field microscopy. Antibody staining can also be used.
Name three medically important spirochete species
Treponema Leptospira Borrelia
What disease is associated with treponema
What diseases are associated with Borrelia
Recurring fevers Lyme disease
What disease is associated with Leptospira
Name the stages of syphilis
Primary Secondary (Latent) Tertiary
Primary syphilis time frame
3 week incubation
Primary syphilis sx
Chancre at site of infection
Secondary syphilis time frame
Develops 2-8 weeks after chancre formation. Lasts days to weeks.
Secondary syphilis sx
Macular papular rash over body surface including soles and palms.
Latent syphilis sx
Essentially none. Low infectivity. May revert to secondary syphilis with high infectivity.
Ixodes ticks feed on small animals and deer. Humans are incidental hosts.
Lyme disease time course
Erythema migrans (bulls eye rash) within first month Secondary progression to debilitating arthritis, cardiovascular disease, and nervous system involvement that can develop immediately or that may be delayed for years.
Lyme disease epidemiology
Outdoor people in the mid-atlantic and new england states
Rodents, cattle, dogs urine contaminated water
Flu-like with meningitis
Etiology: Large inflamed inguinal or axillary lymph node that is very painful that occurs after a visit to the four corners area
Describe pneumonic plaque
Pneumonic involvement of Y. pestis that causes necrotizing hemorrhagic pneumonia with a fatality > 90%
Describe the potential for person to person spread of Y. pestis
Pneumonic involvement is highly contagious.
Yersinia pestis virulence factors
F1 capsular antigen expressed at 37C V and W antigens are antiphagocytic Intracellular survival in macrophage Outer membrane proteins
Similar to plague
Recurrent bacteremia with fever. Infects reticuloendothelial system