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Faculty Of Veterinary Medicine

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Presentation on theme: "Faculty Of Veterinary Medicine"— Presentation transcript:

1 Faculty Of Veterinary Medicine
BIOMOLECULE Faculty Of Veterinary Medicine Airlangga University Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

2 Biomolecule Biomolecules are divided into two namely:     1. STRUCTURAL: constituent tissues / body           organism          Example: collagen, keratin    2. FUNCTIONAL: to carry out the functions          function of life          Example: enzymes, hormones, DNA, RNA, ATP

3 The Diversity of Organic Molecules Makes Life Diverse

4 The chemistry of carbon makes diverse molecules possible
Compounds made of hydrogen and other elements covalently bonded to carbon atoms Organisms consist mainly of oxygen, hydrogen, and carbon Most of the oxygen and hydrogen are in water

5 Carbon has unique bonding properties
Carbon can share electrons with as many as four other atoms Consequently, it can form several different shapes Chains Rings Side branches

6 Each of these organisms uses a different type of structural carbohydrate

7

8 Functional groups add to the diversity of organic molecules
A specific combination of bonded atoms that always react in the same way Example: -OH, the hydroxyl group is hydrophilic and found in alcohol, sugar, and amino acids Isomers – organic molecules with identical molecular formulas, but a different arrangement of atoms

9 Figure 1. Functional groups of organic molecules

10 Molecular subunits can be linked to form macromolecules
Carbohydrates, lipids, proteins, and nucleic acids are called macromolecules because of their large size The largest macromolecules are polymers because they are constructed of many subunits called monomers

11 Dehydration and Hydrolysis
Dehydration reaction synthesizes polymers from monomers by removing water Hydrolysis reaction splits polymers into monomers by adding water

12 Figure 2. Synthesis and degradation of polymers

13 Carbohydrates Are Energy Sources and Structural Components

14 Simple carbohydrates provide quick energy
Used as an immediate energy source Carbon to hydrogen to oxygen ratio = 1:2:1 Monosaccharides contain a single sugar molecule Ribose and deoxyribose are found in DNA Disaccharides contain two monosaccharides joined via dehydration synthesis

15 Three ways to represent glucose, a source of quick energy for this cheetah and all organisms

16 Formation and breakdown of maltose, a disaccharide
Sucrose: Glucose + Fructose   Lactose: Glucose + Galactose

17 Complex carbohydrates store energy and provide structural support
Polymers of monosaccharides Used for short-term or long-term energy storage Animals store glucose as glycogen Plants store glucose as starch Some are used for structure Chitin is used in animals and fungi Cellulose is used by plants

18 Some of the polysaccharides in plants and animals

19 Lipids Provide Storage, Insulation, and Other Functions

20 Fats and oils are rich energy-storage molecules
Hydrophobic biomolecules made of hydrocarbon chains Fats and oils contain glycerol and fatty acids Sometimes called triglycerides

21 Formation and breakdown of a fat

22 Saturated and Unsaturated Fats
Saturated fats have no double bonds They are saturated with hydrogens Unsaturated fats have double bonds They are not saturated with hydrogens

23 Other lipids have structural, hormonal, or protective functions
Phospholipids have hydrophobic tails and hydrophilic heads Found in plasma membranes Steroids are hydrophobic molecules that pass through plasma membranes Waxes are hydrophobic molecules used for waterproofing

24 Phospholipid, cholesterol (a steroid), and wax
3-24

25 Proteins Have a Wide Variety of Vital Functions

26 Proteins are the most versatile of life’s molecules
Important for structure and function 50% of dry weight of most cells Several functions Support Metabolism Transport Defense Regulation Motion

27 Each protein is a sequence of particular amino acids
Proteins are macromolecules with amino acid subunits Made of peptide bonds via dehydration synthesis Polypeptide chain is many amino acids bonded together A protein may have many polypeptide chains

28 Formation and breakdown of a peptide

29 Amino Acids Variety is due to the R group

30 Amino acid diversity. The amino acids are shown in ionized form

31 The shape of a protein is necessary to its function
Denaturation - the irreversible change of protein shape caused by heat or pH Levels of Organization

32 Levels of protein organization

33 Nucleic Acids Are Information Molecules

34 The nucleic acids DNA and RNA carry coded information
DNA – deoxyribonucleic acid The genetic material RNA – ribonucleic acid A copy of DNA used to make proteins Both are polymers of nucleotides monomers Nucleotides are made of a sugar, a nitrogenous base, and a phosphate

35

36 Figure 1. One nucleotide Figure 2. RNA structure

37 Figure 3 DNA structure at three levels of complexity

38 Sequenced the genome of humans Scientists create genetic profiles
APPLYING THE CONCEPTS—HOW BIOLOGY IMPACTS OUR LIVES The Human Genome Project may lead to new disease treatments Sequenced the genome of humans Scientists create genetic profiles Used to predict diseases Examples: Type 2 Diabetes, Schizophrenia Used to make specific treatments

39 The nucleotide ATP is the cell’s energy carrier
Adenosine Triphosphate (ATP) A nucleotide with the base adenine and the sugar ribose making a compound adenosine Hydrolyzes phosphates to release energy and form adenosine diphosphate (ADP)

40 Figure 1. ATP hydrolysis Figure 2. releases energy Animals convert food energy to that of ATP

41 Connecting the Concepts:
Carbon forms the backbone of carbohydrates, lipids, proteins, and nucleic acids The macromolecules of cells are polymers of small organic molecules Simple sugars are the monomers of complex carbohydrates Amino acids are the monomers of proteins Nucleotides are the monomers of nucleic acids Fats are composed of fatty acids and glycerol


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