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ERYTHROPOEISIS HemocytoblastProerythroblast Erythroblast BasophilicPolychroma- tophilic Erythroblast Orthochroma- tophilic Erythroblast Nuclear Extrusion.

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Presentation on theme: "ERYTHROPOEISIS HemocytoblastProerythroblast Erythroblast BasophilicPolychroma- tophilic Erythroblast Orthochroma- tophilic Erythroblast Nuclear Extrusion."— Presentation transcript:

1 ERYTHROPOEISIS HemocytoblastProerythroblast Erythroblast BasophilicPolychroma- tophilic Erythroblast Orthochroma- tophilic Erythroblast Nuclear Extrusion Reticulocyte RBC Pluripotential Stem Cell 1. dispersed chromatin 2. nucleoli 3. cytoplasmic 1. clumped chromatin 2. no nucleoli 3. maximum 1. condensed chromatin 2. grey-green cytoplasm (hemoglobin synthesis) 1. condensed eccentric nucleus 2. pink cytoplasm 1. anucleate 2. spherical 3. slight basophilia (free ribosomes)

2 Erythropoeisis- Several Stages

3 MYELOPOEISIS (granulopoeisis) Hemocytoblast (multipotential) Myeloblast (multipotential) Promyelocyte (multipotential) 1. loss of cytoplasmic basophilia 2. dispersed chromatin EosinophilopoeisisNeutrophilopoeisisBasophilopoeisis

4 EOSINOPHILOPOEISIS Eosinophilic Myelocyte Eosinophilic Metamyelocyte Eosinophil (band cell) Specific and Metachromatic Granules

5 Eosinophilopoeisis- Several Stages

6 NEUTROPHILOPOEISIS NEUTROPHILIC MYELOCYTE NEUTROPHILIC METAMYELOCYTENEUTROPHIL

7 MYELOPOEISIS (Several Stages) Neutrophilic and Eosinophilic Band Cells Nutrophilic Band and Eosinophilic Metamyelocyte

8 BASOPHILOPOEISIS Basophilic Myelocyte Basophilic Metamyelocyte Basophil

9 THROMBOPOEISIS Hemocytoblast Endomytosis (w/o karyokinesis (w/o cytokinesis) Reserve Megakaryocyte (megakaryoblast)Platelet-Forming Megakaryocyte Platelet-Shedding (fusion of plasma membrane) Platelets Residual Megakaryocyte

10 MEGAKARYOCYTES

11 BONE MARROW Decalcified Bone and Marrow Cavity Marrow Fat Cells Bone

12 Marrow Megakaryocyte Adipocyte Diapedesis Hemopoetic Compartment Endothelial Discontinuity Endothelial Cells Blood Sinusoid Reticular Fibers

13 Bone Marrow Bone Marrow in Decalcified Bone Bone Marrow Smear


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