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Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University.

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Presentation on theme: "Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University."— Presentation transcript:

1 Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University

2 Hematopoiesis Simplified: Part 1 Erythropoiesis Objectives are to: Identify the developmental cells of erythropoiesis Characterize developmental changes in the cytoplasm and nucleus of these cells Bone marrow Blood vessel

3 Bone marrow Blood in vessel

4 Peripheral blood Erythrocytes Reticulocytes 21

5 Erythrocytes Reticulocytes Orthochromatophilic erythroblasts Polychromatophilic erythroblasts Basophilic erythroblasts Proerythroblasts No nucleus and red cytoplasm No nucleus and blue - grey cytoplasm Dark, small, spherical nucleus blue – grey cytoplasm Darkening, fractured,spherical nucleus and mixed pools of grey and blue cytoplasm Fractured, spherical nucleus and thin rim of dark blue cytoplasm Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm Erythropoiesis

6 McGraw-Hill Companies

7 Orthochromatophilic erythroblasts Erythrocytes Polychromatophilic erythroblasts Basophilic erythroblasts Proerythroblasts Reticulocytes Erythropoiesis

8 Erythrocytes Orthochromatophilic erythroblasts

9 Orthochromatophilic erythroblast Erythrocyte Polychromatophilic erythroblast Basophilic erythroblast Proerythroblast Reticulocytes Erythropoiesis

10 Polychromatophilic erythroblasts

11 Orthochromatophilic erythroblast Erythrocyte Polychromatophilic erythroblast Basophilic erythroblast Proerythroblast Reticulocytes Erythropoiesis

12 Basophilic erythroblast

13 Orthochromatophilic erythroblast Erythrocyte Polychromatophilic erythroblast Basophilic erythroblast Proerythroblast Reticulocytes Erythropoiesis

14 Proerythroblasts

15 Reticulocytes Erythrocytes Orthochromatophilic erythroblasts Erythropoiesis

16 Early orthochromatophilic erythroblasts Late polychromatophilic erythroblasts

17 Polychromatophilic erythroblastsEarly polychromatophilic erythroblasts

18 Basophilic erythroblastsProerythroblasts

19 ut 112 Polychromatophilic erythroblast Orthochromatophilic erythroblasts Basophilic erythroblast Proerythroblast Late polychromatophilic erythroblast Eosinophil or basophil RBCs platelets Reticulocyte Erythrocytes

20 Bone marrow Reticulocyte entering blood vessel Blood vessel

21 The End of Hematopoiesis Simplified: Part 1 Erythropoiesis

22 Granulopoiesis is next

23 Hematopoiesis Simplified: Part 2 Granulopoiesis Larry Johnson Texas A&M University

24 Hematopoiesis Simplified: Part 2 Granulopoiesis Objectives are to: Identify the developmental cells of granulopoiesis Characterize developmental changes in the cytoplasm and nucleus of these cells Bone marrow 32583

25 Bone marrow Blood

26 ` Bone marrow Developing granulocytes

27 21 Peripheral blood

28 Neutrophilic metamyelocytes Neutrophils Neutrophilic myelocytes Promyelocytes Neutrophilic band or stab cells Lobulated, dark nucleus, mature grey cytoplasm with small granules Horse-shoe shaped, darkening nucleus, grey mature cytoplasm Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules Large, oval, non-indented nucleus, large amount of sky blue cytoplasm with non-specific granules Granulopoiesis

29

30 Neutrophilic band cells Neutrophils Neutrophilic myelocytes Promyelocytes Neutrophilic metamyelocytes Granulopoiesis

31 ut 112 Neutrophilic myelocytes Neutrophilic metamyelocyte Neutrophil Eosinophil or basophil Platelets Neutrophilic metamyelocytes

32 Neutrophilic band cells Neutrophils Neutrophilic myelocytes Promyelocytes Neutrophilic metamyelocytes Granulopoiesis

33 Neutrophilic metamyelocytes Neutrophilic band cells Lymphocytes Neutrophilic myelocytes Lymphocytes Neutrophilic band cell Unknown nuclei Promyelocyte Neutrophilic myelocytes Neutrophilic metamyelocytes Neutrophilic band cells

34 Neutrophilic band cells Neutrophils Granulopoiesis

35 Early neutrophilic metamyelocytes Neutrophilic metamyelocytes

36 Neutrophilic myelocytes

37 Late promyelocytesPromyelocyte

38 Neutrophilic metamyelocytes Proerythroblast Neutrophilic myelocytes Neutrophilic metamyelocytes Orthochromatophilic erythroblasts Orthochromatophilic erythroblasts Unknown nuclei Eosinophils or basophils Neutrophilic band cells

39 32583 White blood cell entering a blood vessel Bone marrow Blood vessel Blood vessel

40 The End of Hematopoiesis Simplified: Part 2 Granulopoiesis


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