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Hematopoeisis VIBS 443/602.

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Presentation on theme: "Hematopoeisis VIBS 443/602."— Presentation transcript:

1 Hematopoeisis VIBS 443/602

2 Peripheral blood smear (May-Grunwald-Giemsa)
113 Peripheral blood smear (May-Grunwald-Giemsa)

3 110 Peripheral blood smear (Leishman-Giemsa) eosinophil, basophil, and neutrophils

4 Bone marrow 19761



7 Bone marrow smear; low power view, showing negative images of fat globules

8 Megakaryocyte: contain many joined nuclei
Megakaryocyte: contain many joined nuclei. Each probably contain 8-32 times a normal diploid amount of DNA Nuclei of megakaryocyte Red blood cell

9 Macrophage: contains greenish, iron-containing granules due to poor quality. Differentiating cells have been torn away during preparation. Macrophage Lymphocyte Neutrophil

10 Pronormoblast Basophilic normoblast Polychromatophilic normoblast Orthochromatic normoblast Myelocyte Late metamyelocytes

11 Pronormoblast Basophilic normoblast Polychromatophilic normoblast Orthochromatic normoblast Myelocyte Late metamyelocytes

12 Late promyelocyte Late myelocyte/early metamyelocyte Nearly mature PMN

13 Smudge cell Promyelocyte Myelocyte Metamyelocytes

14 Pronormoblast Metamyelocytes Band cell

15 Bone marrow: EM 12a Reticular cell Developing red blood cell

16 Bone marrow; EM 8a Lymphocyte PNM Red blood cell eosinophil

17 Bone marrow; EM 12b PMN Immature neutrophil Red blood cell

18 Routine H&E of bone Marrow spicules Lipid in fat cells

19 H&E of bone marrow 1. megakaryocytes

20 19761

21 H&E of bone marrow: Red blood cell

22 Rib 420

23 420 Rib

24 421 Tibia, fetal

25 32583

26 32583

27 Red bone marrow smear (May-Grunwald-Giemsa)
112 Red bone marrow smear (May-Grunwald-Giemsa)



30 Cells of Erythropoisesis
Pronormoblast round nucleus and thin rim of deep blue cytoplasm Basophilic normoblast nuclear condensation ("fractured nucleus") with a deep blue cytoplasm

31 Polychromatophilic normoblast
Polychromatophilic normoblast cytoplasm has accumulated enough hemoglobin so that it is no longer blue but a bluish-gray to bluish-red Orthochromatic normoblast must have an almost mature cytoplasm with only the faintest hint of blue: the nucleus is fully condensed

32 Reticulocyte no nucleus, mature cytoplasm with blue tint Red blood cell typical of mature cell seen in circulation



35 Cells of Granulopoiesis
Promyelocyte oval nucleus with deep blue cytoplasm and azurophilic granules Myelocyte cytoplasm becomes increasingly mature (reddish/clear) but still contains blue, nucleus of variable shape

36 Metamyelocyte deeply indented nucleus with nearly mature cytoplasm (no longer blue) Band cell nucleus just prior to lobulation with fully mature cytoplasm Neutrophil (mature) lobulated nucleus with fully mature cytoplasm





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