1. HyaCare ® Filler CL The topical wrinkle smoother April 2010

2. Consumer Specialties | 18/04/2015Page | 2 Properties & Features HyaCare ® Filler CL is based on a unique, cross-linked polysaccharide made from very pure, fermentation-derived hyaluronic acid a W/O emulsion containing super-absorbing spherical particles preservative free INCI (proposed): Aqua, Ethylhexyl Stearate, Sodium Hyaluronate Crosspolymer, Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate, Sodium Isostearate, Alcohol

3. Consumer Specialties | 18/04/2015Page | 3 Benefits & Claims HyaCare ® Filler CL Instantly fills fine lines & wrinkles Topical alternative to injectables Thoroughly hydrates the skin Increases skin elasticity Smoothes skin surface Start Before application 15 min after application

4. Consumer Specialties | 18/04/2015Page | 4 Cross-linking in emulsion Emulsion Droplets Spherical CL-HA Particles Cross-linking The average particle size distribution of HyaCare ® Filler CL is approx. 700 nm Particle size distribution

5. Consumer Specialties | 18/04/2015Page | 5 Water uptake test Addition of water to the CL-HA W/O emulsion leads to water uptake Water is not taken up by a hyaluronic acid W/O emulsion HyaCare ® Filler CL particles have super-absorbing properties show superior water binding t = 0 min t = 30 min ____20 µm___

6. Consumer Specialties | 18/04/2015Page | 6 In vitro enzymatic degradation - Test design & result HyaCare ® Filler CL is stable against enzymatic degradation supports longer lasting moisturization Method: Measurement of enzymatic cleavage by hyaluronidase Photometrically quantification by determination of released reducing sugars

7. Consumer Specialties | 18/04/2015Page | 7 In vitro MTT-assay – Test design & result HyaCare ® Filler CL protects the skin models from drying out HyaCare ® Filler CL even shows a superior long term effect compared to the vehicle formulation *** ++ *** p<0.001 vs. vehicle (+ cover), ++ p<0.01 vs. vehicle (- cover) Method: Cell viability during drying of skin models (SkinEthic) under laminar flow (rel. to vehicle formulation cultivated at RT with plate cover) MTT-assay

8. Consumer Specialties | 18/04/2015Page | 8 In vitro MTT-assay test – Histology image result HyaCare ® Filler CL leads to a better structured epidermis

9. Consumer Specialties | 18/04/2015Page | 9 Ex vivo wrinkle filling test Design & result HyaCare ® Filler CL particles fill fine lines & wrinkles Fluorescently labelled HyaCare ® Filler CL was applied on pig skin

10. Consumer Specialties | 18/04/2015Page | 10 In vivo evaluation – Test design Test formulation #24 Number of volunteers:16 Application: O/W vehicle with 0.1 % HyaCare ® O/W vehicle with 2.5 % HyaCare ® Filler CL On inner forearm Selected time points:After 2 h Analysis:Corneometer Visioscan VC 98 Observed activity: Skin moisturization Skin surface

11. Consumer Specialties | 18/04/2015Page | 11 In vivo evaluation – Test results Skin moisturization Skin surface HyaCare ® Filler CL thoroughly hydrates the skin smoothes skin surface by reducing number & depth of wrinkles

12. Consumer Specialties | 18/04/2015Page | 12 In vivo evaluation of wrinkles – Test design Application: O/W cream with 5% HyaCare ® Filler CL On face Selected time points:After 15 min & 1h Analysis:Photo

13. Consumer Specialties | 18/04/2015Page | 13 Before application 15 min after application HyaCare ® Filler CL instantly fills fine lines & wrinkles In vivo evaluation of wrinkles – Test result

14. Consumer Specialties | 18/04/2015Page | 14 In vivo evaluation of wrinkles – Test result Before application 1h after application HyaCare ® Filler CL smoothes skin surface

15. Consumer Specialties | 18/04/2015Page | 15 HyaCare ® Filler CL Formulation Hints Recommended usage concentration: 0.5 – 5 % Preparation of an O/W-Emulsion (Cream or Lotion): Normally, HyaCare ® Filler CL should be added to the oil phase of the emulsion. Then the emulsion is prepared as usual. In some cases HyaCare ® Filler CL might disturb the build up of the liquid crystalline structure of the O/W-emulsion. In these cases, it is recommended to add it during the cooling process at temperatures below 40°C. If high concentrations of HyaCare ® Filler CL are used (4 - 5%), it increases the viscosity of the O/W emulsion. In this case, the viscosity can be adjusted by decreasing the concentration of consistency enhancers like fatty alcohols (TEGO ® Alkanol 16, 1618 or 18) and glyceryl stearate (TEGIN ® M Pellets). Preparation of a W/O-Emulsion (Cream or Lotion): The W/O emulsion is prepared as usual. At the end of the production HyaCare ® Filler CL is added.

16. Consumer Specialties | 18/04/2015Page | 16 HyaCare ® Filler CL - Guideline formulation Preparation: 1. Heat phase A and B to approx. 80°C. 2. Add phase A to B while stirring. 3. Homogenize. 4. Cool down to 60°C and add phase C. 5. Homogenize again for a short time. 6. Cool down to 30°C. Add phase D and Z below 40°C. Important: If phase A has to be charged into the vessel first, add phase B without stirring. Dermal Filler Cream (MAC 672/3/1) AAxol ® C 62 Pellets (Glyceryl Stearate Citrate) 1.5 % TEGIN ® M Pellets (Glyceryl Stearate) 3.0 % TEGO ® Alkanol 18 (Stearyl Alcohol) 2.0 % Stearic Acid1.0 % TEGOSOFT ® CT (Caprylic/Capric Triglyceride) 8.5 % TEGOSOFT ® M (Isopropyl Myristate) 7.0 % TEGOSOFT ® CR (Cetyl Ricinoleate) 2.0 % HyaCare ® Filler CL (Aqua; Ethylhexyl Stearate; Sodium Hyaluronate Crosspolymer; Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate; Sodium Isostearate; Alcohol (proposed)) 3.0 % BGlycerin3.0 % Water68.0 % CTEGO ® Carbomer 134 (Carbomer) 0.2 % TEGOSOFT ® CT (Caprylic/Capric Triglyceride) 0.8 % DSodium Hydroxide (10 % in water)q.s. ZPreservative, parfumq.s.

17. Consumer Specialties | 18/04/2015Page | 17 HyaCare ® Filler CL - Guideline formulation Eye Cream (MAC 672/1/1) ATEGO ® Care 450 (Polyglyceryl-3 Methylglucose Distearate) 3.0 % TEGIN ® M Pellets (Glyceryl Stearate) 2.0 % TEGO ® Alkanol 18 (Stearyl Alcohol) 2.0 % TEGOSOFT ® CT (Caprylic/Capric Triglyceride) 7.5 % TEGOSOFT ® DC (Decyl Cocoate) 9.5 % Avocade (Persea Gratissima) Oil2.0 % Tocopheryl Acetate0.5 % HyaCare ® Filler CL (Aqua; Ethylhexyl Stearate; Sodium Hyaluronate Crosspolymer; Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate; Sodium Isostearate; Alcohol (propsosed)) 3.0 % BGlycerin3.0 % Water67.5 % CLactic Acid (10 % in water)q.s. ZPreservative, parfumq.s. Preparation: 1. Heat phase A and B to approx. 80°C. 2. Add phase A to B while stirring. 3. Homogenize. 4. Cool down to 30°C. Add phase C and Z below 40°C. Important: If phase A has to be charged into the vessel first, add phase B without stirring.

18. Consumer Specialties | 18/04/2015Page | 18 Instantly fills fine lines & wrinkles Topical alternative to injectables Thoroughly hydrates the skin Increases skin elasticity Smoothes skin surface Possible applications: Anti-wrinkle eye care products Anti-aging facial serum Special care for expression lines Skin plumping face care Facial sun care Intense moisturizing skin care HyaCare ® Filler CL - Your benefits at a glance

19. Consumer Specialties | 18/04/2015Page | 19

20. Consumer Specialties | 18/04/2015Page | 20 Especially concerning Active Ingredients This product information is not intended to provide legal or regulatory advice about product uses or claims in any jurisdiction and should not be relied upon for such guidance (especially in the United States, Canada, and Mexico). Since global regulatory requirements differ, parties accessing this information are solely responsible for determining whether the products and/or claims comply with applicable local laws and regulations, including but not limited to import and export regulations. Please contact your local Evonik representative for more product information. Evonik assumes no liability for any use of our products that is not in compliance with the requirements of the country of the user.

21. Consumer Specialties | 18/04/2015Page | 21 Glossary CL-HA: cross-linked hyaluronic acid MTT-assay: Is a cell culture test & standard colometric assay for measuring cell viability based on mitochondrial activity. Yellow MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide, a tetrazole) is reduced to purple formazan in living cells.

22. Consumer Specialties | 18/04/2015Page | 22 Particle Size Distribution Method: Detection by SPOS (single particle optical sensing; lower and upper limits of measurement are 0,5 and 400 µm, respectively) Microsope image of dispersion: Back #4

23. Consumer Specialties | 18/04/2015Page | 23 In vitro test design 1) vehicle formulation 1 “normal” cultivation at room temperature with plate-cover under laminar flow 2) vehicle formulation 2 cultivation at room temperature without plate-cover under laminar flow (drying of the skin models) 3) formulation + HyaCare ® Filler CL cultivation at room temperature without plate-cover under laminar flow (drying of the skin models) drying of skin models under laminar flow without plate-cover topical application of testsubstances and incubation in CO 2 -incubator for 1h 4 h8 h 6 h a. analysis of viability (MTT); b. histology of skin models Purpose of the study: Exploration of the physical effect (water-binding capacity) of cross-linked Hyaluronic Acid on dried epidermal skin models. Model: SkinEthic reconstructed human epidermis Back #7

24. Consumer Specialties | 18/04/2015Page | 24 In vivo evaluation – Test formulation MM151/2MM151/6 ATEGO ® Care 450 (Polyglyceryl-3 Methylglucose Distearate) 3.0 % TEGIN ® M Pellets (Glyceryl Stearate) 2.0 % TEGO ® Alkanol 18 (Stearyl Alcohol) 1.0 % TEGOSOFT ® OS (Ethylhexyl Stearate) 9.5 % TEGOSOFT ® CT (Caprylic/Capric Triglyceride) 9.5 % Methylisothiazolinone, Methyl and Ethyl Parabens (Microcare MEM) 0.8 % HyaCare ® 0.1 % HyaCare ® Filler CL2.5 % Water74.1 %71.7 % Back #10