1. GC-MSD Introducing the new 7890B/5977A Badr Astiphan
GCMS Product Sales Specialist
cell
Agilent Confidential
January 8, 2013

2. We are First in GC Continuously innovating
Units Installed
>250,000 GC
>60,000 MS
7000 GC Triple Quad
7200 GC QTOF
Low Thermal Mass
Technology
1970’s
1980’s
1990’s
2000’s
2010’s
Multi-Mode
Inlet
Retention Time
Locking
2nd Gen Linear
Electron Capture
Detector
6890 GC
Electronic Pneumatic
Control
Capillary Flow
Technology
Inert MS Ion Source
Hyperbolic
Gold Quad
5970 MSD
AutoInjection
Fused Silica
Capillary Column
5840 GC
5890 GC
5880 GC
Microprocessor Control
Agilent Confidential
January 8, 2013

3. The industry standard GCMS
7890A/5975C GC/MSD: The Most Popular GC/MS in the World
The industry standard GCMS
Over 20,000
5975 systems since 2005
Agilent Confidential
January 8, 2013

4. Agilent 5977 MSD
Agilent Confidential
January 8, 2013

5. Proven Technologies Improving the Industry Standards for GC/SQ
Gold Quartz Quad
Triple Axis Detector
High Temperature Inert Source
Unique Entrance Lens Design
All of 5975’s features also built in 5977, such as “Gold Quad”, SIM/Scan, Gain tuning, Triple-Axis Detector, Trace Ion Detection, Auto CI, etc..
Agilent Confidential
January 8, 2013

6. High Temperature Ion Source
Solid inert material – not a coating
Not damaged by multiple cleanings
Programmable to 350ºC
Improved response for many compounds
More robust operation for “dirty” samples
Better response for “sticky” compounds
Sharper peaks for high boilers (late eluters)
Polyaromatic Hydrocarbon (PAH)
… more performance for a wide range of applications
Agilent Confidential
January 8, 2013

7. Unique Entrance Lens Eliminates Pre-filter
New, improved lens
Agilent Confidential
January 8, 2013

8. Unique Entrance Lens Eliminates Pre-filter
Fringe fields
Agilent Confidential
January 8, 2013

9. Quartz – Gold – Hyperbolic and Beautiful!
Why quartz?
Low coefficient of linear expansion (expansivity; α)
dL = α L0 dt [t = ºC; dL = change in length (m); L0 = length at 0 ºC]
Why gold?
Inert material with excellent electrical properties for high voltage
Why hyperbolic?
Ideal electrical field is generated by hyperbolic surfaces (NOT ROUND)
Much more than just a beautiful piece of glass
Round Quad
Agilent Confidential
January 8, 2013

10. Triple-Axis Detector Offset Z Y X
With a combination of three axes and appropriate shielding, noise from secondary particles can be reduced to a minimum
Offset Z X Y
ion beam
Agilent Confidential
January 8, 2013

11. Triple Channel EM Exit of the triple channels
Triple channels improve signal amplification
Lower initial EM voltage required
Triple channels increase life
Lower cost of operation
Collector removed to show exit passages
Collector
Agilent Confidential
January 8, 2013

12. Expanded Capabilities: 7890B/5977A Improving the Industry Standards for GC/SQ
Higher Ion Count
Extractor EI source
Increased ion count
S/N > 1500:1
IDL < 10 fg (industry first)
Improved thermal profile
Save Time & Energy
Sequence Scheduler
“Standby” post run
“Ready to run” from standby
“Bake Mode” as needed
Factory backflush option
Fast Vent capability
DS42i rough pump“standby” power reduction
Better Vacuum by Agilent Pump
New Agilent V304 Turbo
TwisTorr
Molecular Drag technology
Improved pumping light gases
H2 (220 L/s); He (255 L/s)
Agilent Floating Suspension
Longer life
Quiet operation
Faster Scanning
20,000 u/s
But never equal to the 7200 Q-TOF speed or ‘scan’ sensitivity
Safety/Protection
Vacuum failure  Shut off gas (He or H2)
7890B GC “Direct Communications Features
EMF, calculator, etc.
Agilent Confidential
January 8, 2013

13. New Extractor Ion Source for 5977
Why the Extractor EI Source?
Increase in ion count
True increase in sensitivity
Better trace level precision
Lower IDL and MDL
Proven sensitivity increase demonstrated with over Series GC/TQ!
Agilent Confidential
January 8, 2013

14. Comparison of Inert and Extractor Ion Source
Repeller
(Push)
Extractor Lens
(Pull)
Extractor Source
Ionization area
Ions
Drawout Plate
Ion Focus Lens
Entrance Lens
Mass Filter
More ions to Mass Filter
Inert Ion Source
Agilent Confidential
January 8, 2013

15. Extractor Source “Etune” Sensitivity Increase
Blue – Extractor 40ppb solution (SVOC)
Red – Standard 40ppb solution (SVOC)
Agilent Confidential
January 6, 2013

16. More improvements on 5977’s Extractor Ion Source: Improved Thermal Profile
Why is this important?
Better performance of high boilers i.e. PAH even at lower concentration!
Good repeatability of PAH even at the trace level (5ppb)!!
10 Injections
80 min analysis
Improvement for better Mass Spectrometer of Gas Chromatograph
January 15, 2013

17. Comparing repeatability of 80min Method
5975 result
Two years ago
5977 result
5977 result
200ppb PAH
5ppb PAH
Phthalates analysis with 5977 GC/MSD
Oct 2012

18. Key features of “Direct Communication” between 7890B and 5977A
Sleep/Wake mode
Sleep mode saves power (320W  190W)
Lower lab operating cost
Safety Control
If 5977A MSD pump fail, 7890B will shut off the gas supply
Helium carrier gas : gas waste is eliminated
Hydrogen carrier gas: risk of explosion is reduced
Cool Down MSD Faster (FastVent)
When MSD Vent Cycle started, GC will cool down MSD analyzer at the optimum gas flow to MSD.
 40% faster when cooling down from 280C to 100C (< 25 min)
Agilent Confidential
January 8, 2013

19. Time saved using Fast Vent
Saving Energy and Time
Power saved
Time saved using Fast Vent
Power( VA)
Source Temp
FastVent
Vent
Time(min)
Time saved

20. Better HW Features: Agilent Turbo Pump (V304)
Innovation for:
Higher pumping performance
especially for He and H2
High reliability
lower cost of operation
Agilent Quality Standard
TwisTorr 304 FS
Press release :
Agilent Confidential
January 8, 2013

21. TwisTorr 304 FS: Vacuum Design
8 EDM turbo stages (rotor) designed to optimize pumping speed for light gases
8 Turbo stators made by pressed SST sheet technology
3 TwisTorr drag stages (spiral channels) designed for high compression ratio performances
Agilent’s new patent-pending Floating Suspension for robust, low noise operation

22. Better HW Features: Agilent Rough Pumps
New DS42i
New IDP-3c
High performance
Energy saving design
“Inverter” not compatible with diff pump
High performance
Oil-free scroll pump
NH3 CI compatible
with Agilent Quality Standards
Agilent Confidential
January 8, 2013

23. Agilent Inert Flow Path … From Injection to Detection
…now from a single supplier
Ultra Inert Inlet Liner
New
Ultimetal Inlet Weldment, Shell and Transfer Lines
Ultimetal – TCD, FPD, NPD/FID Jets
Ultra Inert Gold Seal
Ultimetal Capillary Flow Technology
Devices, Ultimate Union
Ultra Inert GC Column
Agilent Confidential
January 8, 2013

24. Programmable Helium Conservation Module
Works with Gas Saver function of 7890 based GC
Standby Method can be programmed after the sequence ends
Analytical methods are unchanged since Helium is still the carrier during the run

25. 5977A GC/MSD IDL Specification
IDL is a statistically derived value from the precision (%RSD) of 8 consecutive, splitless injections of 100fg OFN at 99 % confidence level. The more precise instruments (lower %RSD) will generate lower IDLs. The Agilent 7890B/5977A with an ALS or CTC autosampler has the following specifications:
Ion Source type
High Vacuum pump type
IDL of OFN by 8 replicates of ALS*
Extractor Source
Turbo Pump
10fg
Inert Source
24fg
Diffusion Pump
30fg
These are installation specification, performed on customer site, immediately after installation and carry a lot more value than a reference specs.
*Systems without an Autosampler will have only S/N specification.
January 15, 2013

26. Why IDL specification is useful for the 5977 in SIM?
Influence of Noise in S/N specs
In SIM (or MS/MS) when the Noise is too low, such as during acquisition of an OFN standard, S/N results may not give the best characterization
If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant
Value of IDL
IDL is derived from reproducibility/precision results, the same metrics most users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance
IDL characterizes the whole system – AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions
January 15, 2013

27. The Influence of the low Noise on S/N values Same Data File, RMS, 5 Second Noise Region
A 0.01 min. shift in the noise region resulted a 6000 higher S/N value.
When the noise is insignificant (low), the derived S/N value is also insignificant!
Noise region: 5.65min min
S/N: 10785
Noise region: 5.66min min
S/N: 3335
S/N
S/N
Noise region: 5.65min-5.73 min
Noise region:
5.66min-5.74 min
January 15, 2013
Confidential, November 14, 2012

28. Market Leading Performance Premium Value: The Best Just Got Better
Detector
Performance
MSD
Scan 1500:1 S/N; SIM 10 fg IDL – Best in Class with IDL tested at installation when ALS or Combi available (with Extractor Source)
FID
<1.4 pg C/sec
ECD
<4.4 fg/sec
FPD
<2.5 pg S/sec; <45 fg P/sec
SCD
<0.5 pg S/sec
NPD
Best for P, 0.08 pg/sec N beat only by Thermo 0.05 pg/sec– but only using OUR Blos bead!
TCD
400 pg/mL
No one can now offer a better specification package than Agilent
Agilent Confidential
January 8, 2013

29. Better science from Agilent
Market’s Best S/N (SNR) > 1500:1
Market’s Best Scan Rate = 20,000 u/s
Market’s ONLY IDL < 10 fg
Better science from Agilent
Statistical confirmation of entire system’s performance
Agilent Confidential
January 8, 2013

30. Mass Hunter GC/MSD Software
MassHunter Qual
MassHunter Quant MH CS
MSD ChemStation DA
MassHunter GC/MS Acquisition
And Use Either
MassHunter Data Analysis OR
MSD ChemStation Data Analysis
G1701FA
Agilent Confidential
January 8, 2013

31. MSD ChemStation DA MSD ChemStation Standard interface Quantitation
QEdit
Macros
Reports
Library Searching
MSD ChemStation DA
Agilent Confidential
January 8, 2013

32. MassHunter WorkStation Qualitative Analysis
Data Navigator
Chromatogram Results
Method Explorer
Method Editor
Spectrum Results
Agilent Confidential
January 8, 2013

33. Mass Hunter Quantitative Analysis
The Quant Batch screen looks like this.
Results Information
Results Information for the batch can be displayed. Visual guides highlight specific data that fall outside specific, predefined conditions.
Compound Information displays graphical representation of the peak, qualifier information, spectral information, and the ISTD. Visual guides help identify associated data problems.
Compound Information
Batch Information
(i.e., Calibration Curve)
Batch Information provides easy visualization and customization of relevant desired data.
Agilent Confidential
January 8, 2013

34. Unknowns Analysis
Agilent Confidential
January 8, 2013

35. MassHunter Excel Reporting
Excel Based (Excel 2010 supported)
MassHunter application exports data in XML and graphics files
Templates define report formatting
Over 100 shipping report templates
Reports can be altered for desired information & appearance
Customization using Excel features (function, formatting, code)
Computer Based Training for report customization by users
Some customization available through Agilent
Agilent Confidential
January 8, 2013

36. Application Notes
Agilent Confidential
January 8, 2013

37. Flexibility: Performance and Budget
Highest
GC Performance
& MS Performance
5977A EI
5977A EI/CI
7890B GC
Extractor source
DS42i
Balance of Price,
GC performance,
& MS performance
5977A Turbo MS
5977A Diff MS
7890B GC
Inert source
Lowest Price
Performance Meets
Method Requirement
5977E Turbo MS
5977E Diff MS
7820A
Stainless source

38. Maintenance and Support Issues
Agilent Confidential
January 8, 2013

39. Q&A Discussion
Agilent Confidential
January 8, 2013