1. Human Systems: Circulatory System

2. Blood

3. Fluid connective tissue Circulates various substances (O2 and nutrients, hormones to different parts of your body) Regulation of body temperature About 5L of blood in human adults Blood is a part of the cardiovascular system (other include the heart and blood vessels)

4. Components of blood Blood contains – plasma (fluid component) – Blood cells (suspended component) Plasma – Contains dissolved substances (water, minerals, proteins, carbohydrates, other complexes, etc.) Blood cells – RBC - Red blood cells (hemoglobin – transport of gases) – WBC - White blood cells (immune system – destroy pathogens-defense against infections) – Platelets (involved in blood clotting)

5. Blood cells Red blood cells – Transport oxygen – Contain hemoglobin – Most abundant cell type

6. Blood cells Platelets – Small in size, pieces of larger cells found in bone marrow – Lasts for 5-10 days – Role in blood clotting

7. Blood cells White blood cells – Destroy pathogens – Help in wound cleaning Modes of action – Some WBCs produce antibodies – Some WBCs produce other chemicals against pathogens – Other eliminate dead or damaged body cells

8. Blood pressure When heart contracts, blood is pushed out The force blood exerts on the walls of arteries is known as blood pressure Expressed in terms of millimeters of mercury (mm Hg) Blood pressure is expressed by two numbers - systolic and diastolic Systolic pressure – pressure in arteries when heart contracts Diastolic pressure - pressure in arteries when heart relaxes Healthy blood pressure: systolic 120 mm Hg, diastolic 80 mm Hg Pulse – rhythmic throbbing of arteries when blood is pumped by heart (around 60 - 70 per minute)

9. Blood types ABO system – A, B, AB or O – Depends on the type of antigens (chemicals) on RBC – Type A has antigen A, B has B,AB has AB and O has none. – It may also depend on the antibodies on the plasma – Blood transfusion means blood injection

10. Blood types Rh System – Another type of antigen on RBC – If antigen if present then Rh+ – If absent then the individual is Rh- – Rh system and transfusion

11. Blood disorders Hemophilia – Problem in blood clotting – Protein required for clotting is missing Leukemia – Blood cancer – Healthy blood cells are not produced Sickle cell anemia – Mutation in hemoglobin – Results is deformed RBCs

12. Cardiovascular system

13. Circulatory fluid (blood) Channels / tubes (blood vessels) Pumping device (heart) Transport of substances Regulation of body temperature Maintenance of homeostasis

14. The heart Muscular organ Divided into four compartments (chambers) Upper chambers: Atrium Lower chambers: Ventricles Left and right sides of the heart are separated by wall The right side of the heart pumps oxygen poor blood to the lungs and left side pumps oxygen rich blood to the body. Valves prevent back flow of blood Repeated opening and closing of valves produce heart beat

15. The heart

17. Blood vessels Hollow tubes for flow of blood Some contain valve to prevent backward blood flow Three types Arteries – Carries blood away from the heart (oxygenated blood) – Pulse is caused by flow of blood into arteries Capillaries – Narrow blood vessels – Allows exchange between body cells and blood Veins – Blood enters from arteries to veins – Carry blood towards heart (deoxygenated)

18. Blood vessels

19. Types of circulation Pulmonary (The circulation of blood between lungs and heart-Oxygen rich) Systemic (The circulation of blood between the heart and rest organs of the body-Oxygen Rich.)

20. Cardiovascular problems Atherosclerosis – Cholesterol and lipids accumulate in blood vessels – This causes narrowing & clogging of vessels and decrease in elasticity High blood pressure – Hypertension – Narrowing or constriction of blood vessels increases pressure – Stroke - blockage or rupture of blood vessels in brain Heart Attack -When heart muscle cells die or get damanged. Heart failure - when heart cant pump enogh blood to meet body needs-organs are damaged by lack of oxygen (brain, kidneys)