1. Circulation What is the pathway of the blood flow in the body?

2. Valves of the Heart Heart needs to prevent the backflow of blood into other chambers. Four valves accomplish this. Composed of dense connective tissue covered by endothelium Two basic types:

3. Atrioventricular Valves Lie between the atria and ventricles Right side is the tricuspid valve –3 flaps –Tendon-like cords –Connect to papillary muscles (look like nipples) Left side is mitral (cone shaped) valve (bicuspid) –2 flaps

4. Semilunar Valves These valves are near the origin of the pulmonary trunk and the aorta. Each has 3 semilunar (half moon-shaped) valves –Attach to artery wall Permit blood flow in one direction Pulmonary valve—pulmonary trunk Aortic valve– opening by ascending aorta and ventricle

6. What is the advantage of a 4- chambered heart? Let’s look at some zoology! There are several different delivery systems.

7. Fish—2 Chambered Heart

8. Amphibians—3 Chambered Heart

9. Reptiles—3 Chambers Reptiles have a partially developed septum between the two ventricles Blood still mixes

10. Mammals—4 Chambered Heart

11. Differences What does endothermic and exothermic mean? Where does blood get oxygenated? How does blood get deoxygenated? Why does the body need oxygen? What else is needed?

12. Vascular System-To the Tissues Taking blood to the tissues and back –Arteries –Arterioles –Capillaries –Venules –Veins

17. Blood Supply of the Heart Heart has its own blood vessels This is called coronary circulation –Left and Right Coronary Arteries –Originate as branches of the ascending aorta. Coronary sinus –Collects the deoxygenated blood –Empties into right atrium

18. Some Heart Problems Many result from faulty coronary circulation Ischemia –Local obstruction of vessels (anemia) –Chest pain –Some other factors Stress Strenuous exercise High blood pressure

19. Valvular Disease Heart murmur –result of turbulent blood flow which is sufficient to produce audible noise. –This most commonly results from narrowing or leaking of valves or the presence of abnormal passages through which blood flows in or near the heart Mitral stenosis –Narrowing of the mitral (bicupsid) valve by scar formation or congenital defect. –Mitral valve prolapse Portion of mitral valve is pushed too far back Blood flows back into left atrium

20. Myocardial infraction (MI) –Heart attack –Death of tissue because of interrupted blood supply –Result from a blood clot in coronary artery –Scar tissue forms Non-contractile –CPR

21. How is heartbeat maintained? Conduction system is the route for nerve impulses (action potentials) Begins in sinoatrial node (SA) –Inferior to opening of vena cava into the atrium –Gap junctions in the intercalated discs conduct –Atria contract –http://www.pennmedicine.org/encyclopedia/e m_DisplayAnimation.aspx?gcid=000001&ptid =57http://www.pennmedicine.org/encyclopedia/e m_DisplayAnimation.aspx?gcid=000001&ptid =57

22. Impulse reaches atrioventricular node (AV) –Action potential slows Travels to the atrioventricular (AV) bundle which is also called the Bundle of His –Action potential conducts from atria to ventricle here

23. Nerve impulse reaches left and right bundle branched –Travel toward the apex of the heart Conduction myofibers called Purkinje fibers conduct to remainder of ventricular myocardium –Ventricle contract!!!

25. Rates of Nodes SA node –90-100 times per minute –Called pacemaker of the heart –Hormones and neurotransmitters speed or slow heartbeat –Typical heartbeat is 75 beats per minute –If SA node is diseased or damaged the AV node can take over 40-50 beats per minute

26. AV bundle will take over if necessary –Only 40-50 beats per minute –Blood flow to the brain is inadequate –Brain uses 20% of the blood

27. Blood Pressure Regular blood pressure is 120/ 80 Systole vs Diastole Atria contract and then relax Ventricles contract then relax Systole is contraction Diastole is relaxation

28. Heart Sounds Lub—AV valves closing Dub—Semilunar valves closing Murmurs –Abnormal sounds –Sometimes thinner walls –Sometimes valve doesn’t close tightly

29. Electrocardiogram See handout!

32. Depolarization - Thus, changes in membrane voltage in which the membrane potential becomes less positive or less negative are both depolarizations. Due to the sodium or calcium. –Causes contraction

33. Normal EKG Pulse rate lies between 60 and 100 beats/minute P-R interval is the time required for completion of atrial depolarization. The normal P-R interval is 0.12 to 0.20 seconds. The QRS interval represents the time required for ventricular cells to depolarize. The normal duration is 0.06 to 0.10 seconds. The Q-T interval is the time required for depolarization and repolarization of the ventricles.