1. Medications Chapter 5

2. Statistics  2009 Most Prescribed  Vicodin  Zokor  Zestril  Levoxyl  Zithromax  Illicit Drugs  Prescription Drugs  Projected Prescription Drug Market, 2016-$500 billion !

3. Side Effects 2005  Serious Adverse Drug Events  Fatal Drug Events  Drug Approval Process (Page 90)  High Cost to Approve and Manufacture Drugs

4. Generic Drugs Patent expires after 20 years, then other companies can manufacture it and it is under its chemical name. Less expensive as there is no research cost 2006- $54 billion in generic drug sales FDA standards are the same for brand name & generics

5. Generics ① Contain essentially identical amts. of identical ingredients in identical doses (Chemical equivalence) ② Must perfom in the same manner as the name brand (Bioequivalence) ③ Must deliver the same amt. of active ingredient into the bloodstream as the name brand (Bioavailability) Generics do not undergo extensive testing & clinical trials

6. Presecription Drug Abuse (pp. 92-93)  In 2009, 20.2% of students had taken prescription drugs w/o a doctor’s Rx, one or more times in their life.  Internet Prescriptions –  Many require no scripts  1/5 of internet pharmacies were under investigation (68 internet pharmacies/2004)  Canadian Pharmacies –safe, lower $$, require Rx, banned but no one has been prosecuted for personal use  Counterfeit Drugs- est. $75 billion market

7. Orphan Drugs  Drugs that treat rare diseases  6,000 conditions that affect less than 200K citizens  Cost is too high for such a small market  Orphan Drug Act of 1983 offers incentives & tax credits, 7 year monopoly and research grants to encourage drug companies to develop these drugs  1983-2010, 347 new drugs developed and reached the market (MS, CF, hemophilia, etc)

8. OTC Drugs No Script Self-Directed Self Diagnosed Non-habit forming 100K OTC w/800 significant active ingredients 178K hospitalizations due to misuse of OTC drugs (Read the label) Interactions with alcohol or other prescription or OTC drugs

9. Common Pain Relievers  Acetaminophen- overuse = liver damage  Alcohol use increases risk  NSAID (Ibuprofen)  Increase risk of gastric/stomach bleeding especially if over 60 on blood thinners, ulcers, or other bleeding issues.  Can damage kidneys  Above safe if used correctly and sparingly Methamphetamine Production- Pseuoephedrine used in above. 2006 law requires ID and limits purchase. BTC designation added to some OTC drugs in Canada