1. Breast Cancer Inheritance
Kelly Grennan, Amanda Rice, Marisa Riehn, Maria Scherer, and Lee Singleton,

2. Pedigree
                                                     I B C D E A II F K G H I J
III N M L IV O

4. BRAC1 and 2 Genes Normally a tumor suppressor genes
BRAC1 on Chromosome 17
BRAC2 on Chromosome 13
Directly control cell proliferation
When both are mutated, they disrupt DNA repair and allow the cell to accumulate mutations including those that foster cancer development

5. Visible Symptoms Lump Swelling Skin Dimpling, irritation or thickening
Nipple pain or sudden inversion
Abnormal discharge
Redness, scaling, or inflammation of the breast or nipple

7. 1:: Have two or more close relatives on your mother´s side been diagnosed with cancer?
::2:: Have two or more close relatives on your father´s side been diagnosed with cancer?
:3:: Have any close relatives, including yourself, been diagnosed with cancer before the age of 50?
:4:: Have you, or a close relative, been diagnosed with two or more distinct cancers, not the spread of cancer from the first cancer site? (Bone, liver, and lung are often sites where cancer spreads, therefore please do not count these cancers as distinct.)

8. ::5:: Has any close relative, including yourself, been diagnosed with any of the following:
Malignant melanoma
Thyroid cancer
Lung cancer (in a non-smoker)
Prostate cancer (before the age of 60)
Male breast cancer
::6:: Has any blood relative who is of Eastern European Ashkenazi Jewish descent, including yourself, been diagnosed with breast, ovarian or colon cancer?

9. ::7:: Have you, or a blood relative, undergone genetic testing and learned of the presence of a gene mutation that causes an increased cancer risk?
::8:: Have you ever been told by a health care professional that you are at an increased risk for cancer?