1. Hunter, D.J., et al. Cohort studies of fat intake and the risk of breast cancer -- a pooled analysis. New England Journal of Medicine. 1996; 334: 356-361. Hunter, D.J., et al. Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer. Cancer Causes and Control. 1997; 8: 49-56. Hunter, D.J., et al. Dietary fat and breast cancer (letter). Journal of the National Cancer Institute. 1998; 90: 1303- 1305. Total Fat and Breast Cancer Publications

2. Sweden Mammography Cohort Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Adventist Health Study Cohort Studies Included in the Pooled Analyses of Total Fat Total = 337,819 # cases = 4,980

3. Cohort Studies Included in the Pooled Analyses of Total Fat Study Total # of Cohort Cases Adventist Health15,172 153 Canadian National56,837 514 Iowa Women’s34,406 723 Netherlands Cohort62,412 434 New York State18,475 376 Nurses’ Health (a)89,046 1,094 Nurses’ Health (b) 68,817 911 Sweden Mammography61,471 775 TOTAL 337,819 4,980 Hunter, et al. 1996

4. % of Energy from Fat Relative Risk Hunter, et al. 1996  Fat and Breast Cancer: Pooled Analysis Pooled RR for Categories of Intake

5. Pooled Multivariate Relative Risks of Breast Cancer and Total Fat by Menopausal Status and Benign Breast Disease Multi. RR (95% CI) p-for- (increment=25g/d) interaction Menopausal Status Premeno.0.98(0.85-1.13) Postmeno. 0.96(0.86-1.08) 0.95 History of Benign Breast Disease No0.95(0.87-1.05) Yes1.29(0.96-1.72) 0.05 Hunter, et al. 1997

6. Pooled Multivariate Relative Risks of Breast Cancer and Total Fat by Family History Multi. RR (95% CI) p-for- (Increment =25g/d) interaction History of breast cancer in mother Yes1.00 (0.77-1.29) No1.02 (0.90-1.15) 0.94 History of breast cancer in sister Yes1.02 (0.74-1.42) No1.05 (0.94-1.18) 0.86 Hunter, et al. 1997

7. Pooled Multivariate Relative Risks of Breast Cancer and Total Fat by Alcohol Intake Alcohol Multi. RR (95% CI) p-for- (g/d) (increment=25g/d) interaction 01.09 (0.93-1.28) >0-<1.51.03 (0.84-1.27) 1.5-<50.97 (0.81-1.17) 5-<151.00 (0.83-1.19) 15-<301.20 (0.93-1.55) >300.77 (0.47-1.28) 0.95 Hunter, et al. 1997