1. Alcohol and Breast Cancer Publications Smith-Warner, S.A., et al. Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA. 1998; 279: 535-540. Smith-Warner, S.A., et al. Alcohol Consumption and Breast Cancer Risk (letter). JAMA. 1998: 1139.

2. Sweden Mammography Cohort Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Cohort Studies in the Pooling Project of Prospective Studies of Diet and Cancer Total = 322,647 # cases = 4,335

3. Cohort Studies Included in the Pooled Analysis of Alcohol and Breast Cancer Canadian National56,837 419 Iowa Women’s34,406 643 Netherlands Cohort62,412 405 New York State18,475 367 Nurses’ Health (a)89,046 1,023 Nurses’ Health (b)68,817 806 Sweden Mammography61,471 672 TOTAL 322,647 4,335 Study Total # of Cohort Cases Smith-Warner, et al. 1998

4. Total Alcohol Intake of Control Participants by Study Canadian National23 13(18) Iowa Women’s 558(11) Netherlands Cohort 329(11) New York State 235(8) Nurses’ Health (a) 3310(13) Nurses’ Health (b) 3610(13) Sweden Mammography 383 (3) *Includes drinkers only Study % Non- Mean* (SD) drinkers (g/d) Smith-Warner, et al. 1998

5. Pooled Relative Risks of Breast Cancer by Categories of Total Alcohol Intake Smith-Warner, et al. 1998 Relative Risk Alcohol (g/d)

6. Total Alcohol Intake and Breast Cancer: Pooling Project Smith-Warner, et al. 1998

7. Study-Specific Relative Risks of Breast Cancer (30-<60 vs. 0 grams per day) Relative Risk.515 Combined Nurses' (b) Nurses' (a) NY State Netherlands Iowa Canada Smith-Warner, et al. 1998

8. Pooled Multivariate Relative Risks of Breast Cancer and Beverage-Specific Alcohol Intake Alcohol Intake RR (95% CI)* Total alcohol1.07(1.01-1.14) Alcohol from beer1.11(1.04-1.19) Alcohol from wine1.05(0.98-1.12) Alcohol from liquor1.05(1.01-1.10) * Increment = 10 grams/day Beverage-specific RRs adjusted for other beverages Smith-Warner, et al. 1998

9. Pooled Multivariate Relative Risks of Breast Cancer and Total Alcohol by Menopausal Status and HRT Use Multi. RR (95% CI) p-for- (increment=10g/d interaction Menopausal Status at Diagnosis Premeno.1.00(0.87-1.15) Postmeno. 1.05(1.01-1.10) 0.49 Hormone Replacement Therapy Use Never1.09(1.03-1.14) Former1.09(1.00-1.18) Current1.06(0.98-1.16) 0.80 Smith-Warner, et al. 1998

10. Pooled Multivariate Relative Risks of Breast Cancer and Total Alcohol by Family History Multi. RR (95% CI) p-for- (increment=10g/d) interaction History of breast cancer in mother Yes0.98(0.85-1.14) No 1.07(1.03-1.11) 0.22 History of breast cancer in sister(s) Yes 1.11(0.96-1.29) No 1.08(1.04-1.12) 0.74 Smith-Warner, et al. 1998

11. Pooled Multivariate Relative Risks of Breast Cancer and Total Alcohol by BMI Multi. RR (95% CI) p-for- (increment=10g/d) interaction Body Mass Index (kg/m 2 ) <211.02(0.91-1.13) >21-23 1.07(1.00-1.14) >23-251.11(1.04-1.18) >25-291.04(0.97-1.11) >291.12(1.02-1.22) 0.31 Smith-Warner, et al. 1998