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2. Chondrosarcoma
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3. Chondrosarcoma Previous Page Next page
Chondrosarcoma is a malignant tumor characterized by the formation of cartilage, but not bone, by the tumor cells.
Frequency in jaws : Rare
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4. Chondrosarcoma Cinical Features Previous Page Next page Age :
Extragnathic : adulthold (6th and 7th decades)
Gnatic (Jaw) : 7th decade (mean age : 41.6)
Gender : Men = Femal
Site : Maxila > Mandible
Sign :
Most common : A painless mass or swelling
Separation or loosening of teeth
Pain : Unusual complaint (In contrast to osteosarcoma )
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5. Chondrosarcoma Radiographic features Previous Page Next page
Radiography :
Radiolucent process with poorly defined borders
Often contains scattered and variable amounts of radiopaque foci
Some : Densely calcified mass with irregular peripheral margins
sunburst pattern (similar to that seen in some osteosarcomas)
Root resorp­tion or symmetrical widening of the periodontal liga­ment space
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6. Chondrosarcoma
کانون رادیواپک
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7. Chondrosarcoma Histopathologic Features Previous Page Next page
Composed of cartilage showing varying degrees of maturation and cellularity.
Typical lacunar formation within the chondroid matrix: In most cases (scarce in poorly differentiated tumors )
Often a lobular growth pattern
Lobules :
Central areas : Greatest degree of maturation
Peripheral areas : Immature cartilage and mesenchymal tissue consisting of round or spindle-shaped cells
Calcification or ossification may occur
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8. Chondrosarcoma Grades Previous Page Next page
Divided into three histo­ pathologic grades :
Grade I chondrosarcomas :
closely mimic the appear­ ance of a chondroma, composed of chondroid matrix and chondroblasts that show only subtle variation from the appearance of normal cartilage.
a tumor should be considered malignant when large, plump chondroblasts and binucleated chondro­ cytes are present
Calcification or ossification of the cartilaginous matrix : often prominent
mitoses : rare.
Grade II chondrosarcomas :
greater pro­ portion of moderately sized nuclei and increased cel­lularity, particularly about the periphery of the lobules.
The mitotic rate : low .
Grade III chondrosarcomas :
highly cellular and may show a prominent spindle cell proliferation.
Mitoses : prominent.
Cells within lacunae : scarce.
Chondrosarcomas of the jaws : predominantly of the histopathologic grades I and II
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9. Chondrosarcoma استروما Previous Page Next page استروما
کندروسیت دوهسته ای
Lacunae
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10. Chondrosarcoma Previous Page Next page کندروسیت تک هسته ای Lacunae
حاشیه لوبول متشکل ازغضروف نابالغ و بافت مزانشیمی شامل سلولهای گرد یا دوکی شکل
مرکز لوبول
حاشیه لوبول
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11. Chondrosarcoma 40x سپتای بافت همبندی بین لوبولها Previous Page
پترن لوبولار
40x
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12. کندورسیتهای داخل لوبولها
Chondrosarcoma
سپتای بافت همبندی بین لوبولها
کندورسیتهای داخل لوبولها
100x
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13. Chondrosarcoma
کندروسیت دوهسته ای
400x
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14. Chondrosarcoma Treatment and Prognosis Previous Page Next page Exit
Most effective treatment : Radical surgical excision
Radiation and chemotherapy : less effective
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