1. Principles and Practice of Radiation Therapy
Chapter 38
Breast Cancer
Supplement: Male Breast Cancer
Copyright © 2010 by Mosby, Inc., an affiliate of Elsevier Inc.

2. Male Breast Cancer General information Epidemiology Etiology
Clinical presentation
Detection and diagnosis
Disease classification
Treatment
Survival

3. Male Breast Cancer
Gynecomastia
Age
Causes
Klinefelter’s syndrome

4. Epidemiology
Incidence
2000 new cases
Deaths
450 deaths
Worldwide

5. Etiology Causes Risk factors BRCA2 BRCA1 Age Family history
Gene mutation
Klinefelter’s syndrome

6. Etiology Risk factors Radiation Alcohol Liver dysfunction
Estrogen therapy
Obesity
Occupation

7. Clinical Presentation
Lump
Skin dimpling
Nipple retraction
Discharge

8. Detection and Diagnosis
Should men be screened for breast cancer?

9. Detection and Diagnosis
Types
Adenocarcinomas
Ductal carcinoma in situ (DCIS)
Infiltrating ductal carcinoma (IDC)
Lobular
Paget’s disease of the nipple

10. Disease Classification
Pattern of spread
Nodes
Site of metastases
Staging
TNM
Same as female
Estrogen receptor/progesterone receptor (ER/PR)
HER2/neu

11. Treatment Surgery Chemotherapy Radiation therapy Mastectomy
Sentinel node biopsy
Chemotherapy
Radiation therapy

12. Survival
Five-year survival rates range from 30-85%