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RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 Knockdown.

Published bySukarno Sugiarto Modified over 5 years ago

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Presentation on theme: "RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 Knockdown."— Presentation transcript:

1 RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 Knockdown of METTL3 significantly suppressed HCC cell proliferation, colony formation, and migration. (A) Stable knockdown of METTL3 in Huh‐7 and HepG2 cells by lentiviral shRNA sequences (shMETTL3#1 and #2). The knockdown effect was verified at both the mRNA and protein levels. (B) Knockdown of METTL3 significantly reduced the proliferation rate of Huh‐7 and HepG2 cells. Mean ± SD. (C) Knockdown of METTL3 impaired colony‐formation ability of HCC cells. (D) Knockdown of METTL3 suppressed HCC cell migration. Bar graphs: Mean ± SD. **P < 0.01, ***P < (t test). Abbreviations: HPRT, hypoxanthine‐guanine phosphoribosyltransferase; shNTC, nontarget control shRNA. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. Hepatology, Volume: 67, Issue: 6, Pages: , First published: 24 November 2017, DOI: ( /hep.29683)

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