1. Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy.
Peanut-specific TH2A cells are specifically targeted during immunotherapy. (A) Ex vivo phenotype of peanut-reactive CD4+ T cells before and after DBPCFC with peanut flour. Each dot represents a single donor. (B) Ex vivo frequency of peanut-reactive CD4+ T cells before and after DBPCFC. (C) Plots show representative ex vivo profile of peanut-reactive CD4+ T cells according to CD27, CD161, and CRTH2 expression before and after CODIT both in placebo and active groups. Data are representative of at least three donors per group. Percentages of CD27− allergen-specific T cells expressing the given marker are indicated in the upper left quadrant. (D) Ex vivo peanut-specific TH2A cell frequencies before and after CODIT both in placebo (n = 3) and active (n = 4) groups. Differences between groups were analyzed by using the Wilcoxon matched pairs test (A and B) and unpaired t test (D). *P < 0.05.
Erik Wambre et al., Sci Transl Med 2017;9:eaam9171
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