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Airway microbiome and responses to corticosteroids in corticosteroid-resistant asthma patients treated with acid suppression medications  Elena Goleva,

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Presentation on theme: "Airway microbiome and responses to corticosteroids in corticosteroid-resistant asthma patients treated with acid suppression medications  Elena Goleva,"— Presentation transcript:

1 Airway microbiome and responses to corticosteroids in corticosteroid-resistant asthma patients treated with acid suppression medications  Elena Goleva, PhD, J. Kirk Harris, PhD, Charles E. Robertson, PhD, Leisa P. Jackson, BS, Richard J. Martin, MD, Donald Y.M. Leung, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 3, Pages e1 (September 2017) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Changes in the airway microbiome composition of CR asthmatics treated with acid suppression medications. Distribution of major bacterial phyla based on 16S ribosomal RNA (rRNA) sequencing data of BAL samples of CR asthmatics on and not on acid suppression medications is provided. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Effects of different Streptococci on primary bronchial epithelial cells activation and response to corticosteroids in vitro. A and B, p38 MAPK activation in the cells as detected by Western blot. C and D, Cellular production of mitogen-induced kinase phosphatase 1 (MKP-1) and IL-8 mRNA in response to corticosteroids in vitro as shown by real-time PCR. The experiments were done in 3 different primary bronchial epithelial cell lines. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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