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Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components  Stephen R. Reeves, MD, PhD, Tessa.

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Presentation on theme: "Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components  Stephen R. Reeves, MD, PhD, Tessa."— Presentation transcript:

1 Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components  Stephen R. Reeves, MD, PhD, Tessa Kolstad, BS, Tin-Yu Lien, BS, Molly Elliott, BS, Steven F. Ziegler, PhD, Thomas N. Wight, PhD, Jason S. Debley, MD, MPH  Journal of Allergy and Clinical Immunology  Volume 134, Issue 3, Pages e1 (September 2014) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Expression of COL1A1 mRNA by HLFs alone compared with coculture with AECs from healthy subjects or AECs from asthmatic patients. B, Expression of COL3A1 mRNA by HLFs alone compared with coculture with AECs from healthy subjects or AECs from asthmatic patients. C, Expression of HAS2 mRNA by HLFs alone compared with coculture with AECs from healthy subjects or AECs from asthmatic patients. D, Expression of fibronectin (FNDC) by HLFs alone compared with coculture with AECs from healthy subjects or AECs from asthmatic patients. GAPDH, Glyceraldehyde-3-phosphate dehydrogenase. ∗P = .002, #P = .02, §P = .005, and ¶P = .05. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Collagen III expression assessed by using IHC among HLFs alone (A), HLFs plus AECs from healthy subjects (B), and HLFs plus AECs from asthmatic patients (C). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Hyaluronic Acid expression assessed by using IHC among HLFs alone (A), HLFs plus AECs from healthy subjects (B), and HLFs plus AECs from asthmatic patients (C). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 A, Concentrations of TGF-β1 measured in culture media collected at 96 hours from HLFs alone compared with cocultures of AECs from healthy subjects and HLFs and cocultures of AECs from asthmatic patients and HLFs (lines at means with SDs). B, Concentrations of TGF-β2 measured in culture media collected at the 96-hour time point from HLFs alone, cocultures of HLFs plus AECs from healthy subjects, and cocultures of HLFs plus AECs from asthmatic patients (lines at medians with interquartile ranges). ∗P = .01. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 PGE2S mRNA expression is depicted on the left side of the figure in either AECs from asthmatic patients or AECs from healthy subjects. The right side of the figure demonstrates mRNA expression of PTGS2/COX-2 in AECs from asthmatic patients or AECs from healthy subjects, respectively. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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