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Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration  Jean-Olivier Defraigne, MD, PhD,

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Presentation on theme: "Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration  Jean-Olivier Defraigne, MD, PhD,"— Presentation transcript:

1 Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration  Jean-Olivier Defraigne, MD, PhD, Joël Pinc , PhD, Robert Larbuisson, MD, PhD, Francine Blaffart, RN, Raymond Limet, MD, PhD  The Annals of Thoracic Surgery  Volume 69, Issue 4, Pages (April 2000) DOI: /S (00)

2 Fig 1 Postoperative blood loss after 24 hours. (HCO-A = heparin-coated group with aprotinin; HCO = heparin-coated group without aprotinin; C-A = uncoated group with aprotinin; C = uncoated group without aprotinin.) The Annals of Thoracic Surgery  , DOI: ( /S (00) )

3 Fig 2 TNF-α concentration. (HCO-A = heparin-coated group with aprotinin; HCO = heparin-coated group without aprotinin; C-A = uncoated group with aprotinin; C = uncoated group without aprotinin. T1 = after the induction of anesthesia; T2 = 5 minutes after aorta unclamping; T3 = after protamine administration; T4 = 24 hours after protamin administration.) The Annals of Thoracic Surgery  , DOI: ( /S (00) )

4 Fig 3 IL-6 concentration. (HCO-A = heparin-coated group with aprotinin; HCO = heparin-coated group without aprotinin; C-A = uncoated group with aprotinin; C = uncoated group without aprotinin. T1 = after the induction of anesthesia; T2 = 5 minutes after aorta unclamping; T3 = after protamine administration; T4 = 24 hours after protamine administration.) The Annals of Thoracic Surgery  , DOI: ( /S (00) )

5 Fig 4 IL-8 concentration. (HCO-A = heparin-coated group with aprotinin; HCO = heparin-coated group without aprotinin; C-A = uncoated group with aprotinin; C = uncoated group without aprotinin. T1 = after the induction of anesthesia; T2 = 5 minutes after aorta unclamping; T3 = after protamine administration; T4 = 24 hours after protamine administration.) The Annals of Thoracic Surgery  , DOI: ( /S (00) )

6 Fig 5 MPO concentration. (HCO-A = heparin-coated group with aprotinin; HCO = heparin-coated group without aprotinin; C-A = uncoated group with aprotinin; C = uncoated group without aprotinin. T1 = after the induction of anesthesia; T2 = 5 minutes after aorta unclamping; T3 = after protamine administration; T4 = 24 hours after protamine administration.) The Annals of Thoracic Surgery  , DOI: ( /S (00) )

7 Fig 6 Elastase concentration. (HCO-A = heparin-coated group with aprotinin; HCO = heparin-coated group without aprotinin; C-A = uncoated group with aprotinin; C = uncoated group without aprotinin. T1 = after the induction of anesthesia; T2 = 5 minutes after aorta unclamping; T3 = after protamine administration; T4 = 24 hours after protamine administration.) The Annals of Thoracic Surgery  , DOI: ( /S (00) )

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