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Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery  Massimo Chello, MD, Amedeo Anselmi, MD, Cristiano.

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Presentation on theme: "Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery  Massimo Chello, MD, Amedeo Anselmi, MD, Cristiano."— Presentation transcript:

1 Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery 
Massimo Chello, MD, Amedeo Anselmi, MD, Cristiano Spadaccio, MD, Giuseppe Patti, MD, Costanza Goffredo, MD, Germano Di Sciascio, MD, Elvio Covino, MD  The Annals of Thoracic Surgery  Volume 83, Issue 4, Pages (April 2007) DOI: /j.athoracsur Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Cytokine production during and after coronary bypass operation in placebo (squares), statin (triangles) and off-pump (circles) groups. Sampling points are before induction of anesthesia (baseline), at the end of operation (end), and at 4, 24, 48, and 72 hours postoperatively. Error bars indicate the standard deviation of the mean. (A) Interleukin-8 (IL-8) production; (B) interleukin-6 (IL-6) production; and (C) tumor necrosis factor-α (TNF-α). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 (A) Spontaneous apoptosis after 12 and 24 hours of culture of neutrophils from off-pump subjects (clear bars) and from patients undergoing cardiopulmonary bypass with either statin (diagonal fill) treatment or placebo (black bars). Error bars indicate the standard deviation of the mean. (**p < 0.01 and *p < 0.05 versus statin group.) (B) Fluorometric analysis of caspase-3-like activity measured by Asp-Glu-Val-Asp-cleaving activity in the off-pump (circles), statin (triangles), and placebo (squares) groups. Error bars indicate the standard deviation of the mean. (*p < 0.05 versus the statin group.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 (A) Nitro-blue tetrazolium scores of circulating neutrophils. Each bar represents the median ± SD of 15 values in placebo (black bars), statin (diagonal bars), and off-pump (clear bars) groups after 8, 12, and 24 hours of culturing. (*p < 0.05 and **p < 0.01 versus statin group.) (B) Expression of CD11b/CD18 on the surface of neutrophils. Each point represents the median ± SD of 15 values in the placebo (squares), statin (triangles), and off-pump (circles) groups after 8, 12 and 24 hours of culturing. (**p < 0.01 versus statin group.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

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