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Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts  Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,

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Presentation on theme: "Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts  Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,"— Presentation transcript:

1 Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts 
Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD, Susanne Lau, MD, PhD, Thomas Keil, MD, MScPH, Ulrich Wahn, MD, Oliver Fuchs, MD, PhD, Petra Ina Pfefferle, PhD, DrPH, Elisabeth Schmaußer-Hechfellner, BSc, Jon Genuneit, MD, Roger Lauener, MD, Anne M. Karvonen, PhD, Caroline Roduit, MD, Jean-Charles Dalphin, MD, PhD, Josef Riedler, MD, Juha Pekkanen, MD, PhD, Erika von Mutius, MD, Markus J. Ege, MD Carl Peter Bauer, Johannes Forster, Fred Zepp, Volker Wahn, Antje Schuster, Renate L. Bergmann, Karl E. Bergmann, Andreas Reich, Linus Grabenhenrich Bianca Schaub, Georg J. Loss, Harald Renz, Michael Kabesch, Marjut Roponen, Anne Hyvärinen, Pekka Tiittanen, Sami Remes, Charlotte Braun-Fahrländer, Remo Frei, Vincent Kaulek, Marie-Laure Dalphin, Gert Doekes, Nicole Blümer, Urs Frey Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD, Susanne Lau, MD, PhD, Thomas Keil, MD, MScPH, Ulrich Wahn, MD, Oliver Fuchs, MD, PhD, Petra Ina Pfefferle, PhD, DrPH, Elisabeth Schmaußer- Hechfellner, BSc, Jon Genuneit, MD, Roger Lauener, MD, Anne M. Karvonen, PhD, Caroline Roduit, MD, Jean-Charles Dalphin, MD, PhD, Josef Riedler, MD, Juha Pekkanen, MD, PhD, Erika von Mutius, MD, Markus J. Ege, MD Carl Peter Bauer, Johannes Forster, Fred Zepp, Volker Wahn, Antje Schuster, Renate L. Bergmann, Karl E. Bergmann, Andreas Reich, Linus Grabenhenrich Bianca Schaub, Georg J. Loss, Harald Renz, Michael Kabesch, Marjut Roponen, Anne Hyvärinen, Pekka Tiittanen, Sami Remes, Charlotte Braun- Fahrländer, Remo Frei, Vincent Kaulek, Marie-Laure Dalphin, Gert Doekes, Nicole Blümer, Urs Frey Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD, Susanne Lau, MD, PhD, Thomas Keil, MD, MScPH, Ulrich Wahn, MD, Oliver Fuchs, MD, PhD, Petra Ina Pfefferle, PhD, DrPH, Elisabeth Schmaußer-Hechfellner, BSc, Jon Genuneit, MD, Roger Lauener, MD, Anne M. Karvonen, PhD, Caroline Roduit, MD, Jean-Charles Dalphin, MD, PhD, Josef Riedler, MD, Juha Pekkanen, MD, PhD, Erika von Mutius, MD, Markus J. Ege, MD Carl Peter Bauer, Johannes Forster, Fred Zepp, Volker Wahn, Antje Schuster, Renate L. Bergmann, Karl E. Bergmann, Andreas Reich, Linus Grabenhenrich Bianca Schaub, Georg J. Loss, Harald Renz, Michael Kabesch, Marjut Roponen, Anne Hyvärinen, Pekka Tiittanen, Sami Remes, Charlotte Braun-Fahrländer, Remo Frei, Vincent Kaulek, Marie-Laure Dalphin, Gert Doekes, Nicole Blümer, Urs Frey  Journal of Allergy and Clinical Immunology  Volume 139, Issue 6, Pages e12 (June 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Journal of Allergy and Clinical Immunology 2017 139, 1935-1945
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 1 A and B, Selection of study populations.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 2 LCs of atopy as characterized by allergen specificity, time course, and sIgE levels. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 3 Associations of asthma-related conditions with LCs and classical definitions of atopic sensitization at age 6 years. *Because there was no case of lifetime asthma in this LC, we calculated a conservative estimation of the odds ratio (OR) based on one case of asthma in this LC, which was simulated at random. Black point estimates with error bars mark the LCs as reference, red marks the classical definitions as a comparison. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 4 Atopy phenotypes in relation to the distribution of LCs in both populations. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 5 Absolute sIgE levels (A) and ratio of IL-5 to IFN-γ expression (B) at age 6 years. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig 6 Path diagram comparing severe atopy with the other atopy phenotypes, including its features, lung function, and asthma in both populations. Excessive sIgE production is defined as incremental increase of seasonal sIgE production during the first 6 years. High sIgE levels are determined at age 6 years. Significant associations are shown by solid arrows. Absent associations are represented by interrupted dotted arrows. Values represent association estimates from the final model, including significant paths only. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig 7 Proportion of nonasthmatic children with reduced lung function by LCs. Reduced lung function was defined as values in the lowest decile of the FEV1 distribution. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Fig E1 Distribution of LCs across study centers.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

11 Fig E2 Prediction of LCs by classical definitions of sensitization at age 6 years. Dots mark the sensitization status (from right to left: unsensitized and CAP classes 1-3). Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

12 Fig E3 Associations of health conditions with LCs and classical definitions of atopic sensitization at age 6 years. *Because there was no case of late-onset wheeze in this LC, we calculated a conservative estimation of the OR based on 1 case of late-onset wheeze in this LC, which was simulated at random. Black point estimates with error bars mark the LCs as reference, and red marks the classical definitions as comparison. Late-onset wheeze was defined as described by Depner et al.3 Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

13 Fig E4 Associations of LCs with parental atopy.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

14 Fig E5 Sensitivity analyses omitting single dimensions of LCA.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

15 Fig E6 Comparing disease associations across all sensitivity analyses. *Because there was no case of lifetime asthma in this LC, we calculated a conservative estimation of the odds ratio (OR) based on 1 case of asthma in this LC, which was simulated at random. Black point estimates with error bars mark the LCs as reference, and red marks the classical definitions as a comparison. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

16 Fig E7 Number of sensitizations to different allergen specificities across LCs (CAP classes 1-3). Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

17 Fig E8 Absolute sIgE levels at age 6 years.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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