Presentation is loading. Please wait.

Presentation is loading. Please wait.

Markus J. Ege, MD, David P. Strachan, MD, William O. C. M

Published byBruno Moore Modified over 5 years ago

Similar presentations

Presentation on theme: "Markus J. Ege, MD, David P. Strachan, MD, William O. C. M"— Presentation transcript:

1 Gene-environment interaction for childhood asthma and exposure to farming in Central Europe 
Markus J. Ege, MD, David P. Strachan, MD, William O.C.M. Cookson, MD, DPhil, Miriam F. Moffatt, MD, DPhil, Ivo Gut, PhD, Mark Lathrop, PhD, Michael Kabesch, MD, Jon Genuneit, MD, Gisela Büchele, PhD, Barbara Sozanska, MD, Andrzej Boznanski, MD, PhD, Paul Cullinan, MD, Elisabeth Horak, MD, Christian Bieli, MD, Charlotte Braun-Fahrländer, MD, Dick Heederik, PhD, Erika von Mutius, MD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 1, Pages e4 (January 2011) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Selection of the study population.
Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Genome-wide interaction analysis for asthma phenotypes. Bonferroni-corrected interaction P values are plotted against the genomic SNP position. The red line represents the effective significance level of .05. The blue dots represent the P values for interactions of farming and related exposures with asthma, the red dots with atopic asthma, and the green dots with nonatopic asthma. The yellow diamonds mark genes represented by at least 2 SNPs. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Genome-wide interaction analysis for atopy. Bonferroni-corrected interaction P values are plotted against the genomic position of the SNPs. The red line represents the effective significance level of .05. Blue dots represent P values for interactions of farming and related exposures with specific IgE ≥0.35 kU/L and red dots with specific IgE ≥3.5 kU/L. The yellow diamonds mark genes represented by at least 2 SNPs. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Power calculation for the genome-wide interaction analysis for asthma with farming as environmental exposure. The power to detect full effect concentrations (blue lines), mild crossover interactions (red lines), and strong crossover interactions (green lines) is given for interacting allele frequencies ranging from 0.1 to 0.9 for genome-wide significance (α = 0.05 corrected for 500,000 SNPs; A) and single hypotheses (α = 0.05; B). The dotted lines indicate 50% and 95% power in A and B, respectively. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Markus J. Ege, MD, David P. Strachan, MD, William O. C. M"

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children  Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children  Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.
Novel severe wheezy young children phenotypes: Boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze  Jocelyne Just, PhD, MD, Rahele Gouvis-Echraghi,

Novel severe wheezy young children phenotypes: Boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze  Jocelyne Just, PhD, MD, Rahele Gouvis-Echraghi,
Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O
Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children  Markus Johannes.

Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children  Markus Johannes.
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts  Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,

Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts  Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion  Anna Lluis, MSc, Michaela Schedel,

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion  Anna Lluis, MSc, Michaela Schedel,
Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study  Georg Loss, MSc, Sondhja Bitter, MD, Johanna Wohlgensinger,

Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study  Georg Loss, MSc, Sondhja Bitter, MD, Johanna Wohlgensinger,
TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants  Kathrin Suttner, MSc, Philip Rosenstiel, MD, Martin Depner, MSc,

TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants  Kathrin Suttner, MSc, Philip Rosenstiel, MD, Martin Depner, MSc,
Georg Loss, PhD, Martin Depner, PhD, Laurien H. Ulfman, PhD, R. J

Georg Loss, PhD, Martin Depner, PhD, Laurien H. Ulfman, PhD, R. J
Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 
Atopic sensitization in the first year of life

Atopic sensitization in the first year of life
A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom  Yize I. Wan, BMedSci, David P. Strachan,

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom  Yize I. Wan, BMedSci, David P. Strachan,
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Prediction of the incidence, recurrence, and persistence of atopic dermatitis in adolescence: A prospective cohort study  Astrid S. Peters, MD, MSc, Jessica.

Prediction of the incidence, recurrence, and persistence of atopic dermatitis in adolescence: A prospective cohort study  Astrid S. Peters, MD, MSc, Jessica.
Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study  Petra Ina.

Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study  Petra Ina.
An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Similar presentations

Ads by Google