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Markus J. Ege, MD, David P. Strachan, MD, William O. C. M

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Presentation on theme: "Markus J. Ege, MD, David P. Strachan, MD, William O. C. M"— Presentation transcript:

1 Gene-environment interaction for childhood asthma and exposure to farming in Central Europe 
Markus J. Ege, MD, David P. Strachan, MD, William O.C.M. Cookson, MD, DPhil, Miriam F. Moffatt, MD, DPhil, Ivo Gut, PhD, Mark Lathrop, PhD, Michael Kabesch, MD, Jon Genuneit, MD, Gisela Büchele, PhD, Barbara Sozanska, MD, Andrzej Boznanski, MD, PhD, Paul Cullinan, MD, Elisabeth Horak, MD, Christian Bieli, MD, Charlotte Braun-Fahrländer, MD, Dick Heederik, PhD, Erika von Mutius, MD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 1, Pages e4 (January 2011) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Selection of the study population.
Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Genome-wide interaction analysis for asthma phenotypes. Bonferroni-corrected interaction P values are plotted against the genomic SNP position. The red line represents the effective significance level of .05. The blue dots represent the P values for interactions of farming and related exposures with asthma, the red dots with atopic asthma, and the green dots with nonatopic asthma. The yellow diamonds mark genes represented by at least 2 SNPs. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Genome-wide interaction analysis for atopy. Bonferroni-corrected interaction P values are plotted against the genomic position of the SNPs. The red line represents the effective significance level of .05. Blue dots represent P values for interactions of farming and related exposures with specific IgE ≥0.35 kU/L and red dots with specific IgE ≥3.5 kU/L. The yellow diamonds mark genes represented by at least 2 SNPs. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Power calculation for the genome-wide interaction analysis for asthma with farming as environmental exposure. The power to detect full effect concentrations (blue lines), mild crossover interactions (red lines), and strong crossover interactions (green lines) is given for interacting allele frequencies ranging from 0.1 to 0.9 for genome-wide significance (α = 0.05 corrected for 500,000 SNPs; A) and single hypotheses (α = 0.05; B). The dotted lines indicate 50% and 95% power in A and B, respectively. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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