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Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis  Susanne.

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Presentation on theme: "Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis  Susanne."— Presentation transcript:

1 Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis  Susanne M. Henning, Piwen Wang, Jonathan Said, Clara Magyar, Brandon Castor, Ngan Doan, Carmen Tosity, Aune Moro, Kun Gao, Luyi Li, David Heber  Journal of Nutritional Biochemistry  Volume 23, Issue 11, Pages (November 2012) DOI: /j.jnutbio Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Fig. 1 Body weight (A) and tumor volume (B) of SCID mice inoculated with LAPC4 prostate tumor cells and treated with brewed green tea or water (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2012 Elsevier Inc. Terms and Conditions

3 Fig. 2 Concentration of total (free+conjugated) GTPs and their methyl metabolites in tumor tissue of mice treated with green tea (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2012 Elsevier Inc. Terms and Conditions

4 Fig. 3 (A) Gene expression of DNMT1 and (B) protein expression of DNMT1 in tumor tissue of mice treated with tea or water determined by quantitative real-time PCR (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2012 Elsevier Inc. Terms and Conditions

5 Fig. 4 Oxidative DNA damage (A) in xenograft LAPC4 tumor or normal prostate tissue in intact (I) or castrated (C) mice; significant difference between tumor and prostate in intact (♦) and castrated mice (⁎). (B) Oxidative damage in tumor tissue and (C) oxidative protein damage in tumor tissue of mice treated with green tea or water (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2012 Elsevier Inc. Terms and Conditions

6 Fig. 5 Protein expression of (A) HIF-1α and (B) VEGF in tumor tissue of mice treated with green tea or water by Western blot and (C) microvessel density by immunohistochemistry (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2012 Elsevier Inc. Terms and Conditions

7 Fig. 6 Macrophage presence in tumor tissue of mice treated with green tea (A) or water (B) by F4/80 immunohistochemistry staining (×50 magnification). Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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