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Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic.

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Presentation on theme: "Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic."— Presentation transcript:

1 Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring  M. Li, C.M. Reynolds, D.M. Sloboda, C. Gray, M.H. Vickers  Journal of Nutritional Biochemistry  Volume 26, Issue 3, Pages (March 2015) DOI: /j.jnutbio Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Fig. 1 Maternal plasma lipid concentrations. Values are presented as mean±S.E.M., n=7–9 per group. Comparisons between groups for each effect where significant are indicated by the bar, P<.05. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

3 Fig. 2 Maternal HOMA-IR indices. Values are presented as mean±S.E.M., n=7–9 per group. Comparisons between groups for each effect where significant are indicated by the bar, P<.05. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

4 Fig. 3 Maternal plasma proinflammatory cytokine profiles. Values are presented as mean±S.E.M., n=7–9 per group. Comparisons between groups for each effect where significant are indicated by the bar, P<.05. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

5 Fig. 4 Maternal liver histology. H&E staining, 40× magnification, representative micrographs from each experimental group: (A) CON group, (B) CT group, (C) F group, (D) FT group. n=7–9 per group. Two sections per animal were examined under 5×, 20× and 40× magnification, respectively. Representative images were taken under 40× magnification. At least 10 random fields per animal were evaluated for NAS grading. Significant microvesicular steatosis characterized by small intracytoplasmic fat vacuoles was observed in the F group along with sparse macrovesicular steatosis characterized by round-shaped empty space between hepatocytes. CON, CT and FT groups showed normal liver morphology. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

6 Fig. 5 Maternal hepatic gene expression. Values are presented as mean±S.E.M., n=7–9 per group. Comparisons between groups for each effect where significant are indicated by the bar, P<.05. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

7 Fig. 6 Neonatal hepatic gene expression. Values are presented as mean±S.E.M., n=7–9 per group. Comparisons between groups for each effect where significant are indicated by the bar, P<.05. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

8 Supplementary Fig. 1 (a) Total caloric intake (chow intake (CON and CT groups) plus additional calories derived from fructose (F and FT groups) during pregnancy and lactation; (b) Food intake — total chow intake (grams) during pregnancy and lactation and (c) total fluid intake during pregnancy and intake (grams) during pregnancy and lactation and (c) total fluid intake during pregnancy and ANOVA analysis. Data are means±S.E.M. with 7–9 dams per group. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

9 Supplementary Fig. 2 Neonatal hepatic gene expression of markers related to IR and lipid metabolism. Values are presented as mean±S.E.M, n=7–9 per group. Journal of Nutritional Biochemistry  , DOI: ( /j.jnutbio ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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