1. II IMB Meeting - Addis Ababa, October 13 2011 Integrated training activities and IT infrastructures to improve capacities in eastern African area JP.2009.10800.002 Project status with respect to planned objectives Francesca Incardona (EuResist Network GEIE)

2. 2 II IMB Meeting - Addis Ababa, October 13 2011 Integrated training activities and IT infrastructures to improve capacities in eastern African area Started: May 2010 Will end: May 2013 WP 1 Project management WP 2 Clinical Trials WP 3 Capacity Building WP 4 Networking

3. 3 II IMB Meeting - Addis Ababa, October 13 2011 Project Management structure  Project coordinator: Anders Sonnerborg : scientific management – financial management - overall progress of the project  WP1 project management coordinator: Francesca Incardona: administrative, day by day coordination  International Management Board: Anders Sonnerborg, Francesca Incardona, Mario Toti, Maurizio Zazzi, Njogu Washington, Ferdinand Mugusi, Daniel Fekade: implementation of actions  WP coordinators: implementation of actions in the WPs:  WP 2 Clinical Trials: Maurizio Zazzi  WP 3 Capacity building: Daniel Fekade  WP 4 Networking: Muhammed Bakari  Local Work-group Coordinators: Njogu Washington, Ferdinand Mugusi, Daniel Fekade : implementation of actions in Kenya, Tanzania, Ethiopia

4. 4 II IMB Meeting - Addis Ababa, October 13 2011 WP 1 Activities Main responsible Targets/Milestones2010201120122013 1.1 Contract preparations with EDCTP Project coordinator and EDCTP A signed contract with EDCTP Q2 1.2 Establishment of the international management board (IMB) Project coordinator A documented defining the IMB Q2 1.3 Prepare study data management plan Members of IMB A complete data management plan Q4 1.4 Privacy agreement for merge of local data to the EuResist database Project coordinator, Local Work- Group coord., EuResist represent. Privacy agreements between EuResist and each of the African partners Q4 1.6 IMB meeting 2 (in situ and/or TC) Members of IMB Meeting notes Q1 1.7 IMB meeting 3 (in situ and/or TC) Members of IMB Meeting notes Q1 1.8 IMB meeting 4 (in situ and/or TC) Members of IMBMeeting notes Q1 I believe two more TC meetings per year are necessary, to monitor activities WP1 Management

5. 5 II IMB Meeting - Addis Ababa, October 13 2011 WP1 Activities Main responsible Targets/Milesto nes 201020112012201 3 1.10 Creating costs statements for each project period Project coordinator, Local Work- Group coord. Periodic costs statements Q2 1.11 Creating a final report of the activities in WP1-W4 Project coordinator Final report Q2 1.12 Translation of results and findings from the project to the public Project coordinator Dissemination plan Q1 1.13 Dissemination of findings to the public Each WP- leader List of dissiminations Q2 WP1 Management

6. 6 II IMB Meeting - Addis Ababa, October 13 2011 WP2 Activities Main responsible Targets/Milestones2010201120122013 Clinical trial 2.1 Protocol development for the study on merged data WP2 leaderClinical protocolQ4 2.2 Clinical trial registration with the EDCTP ATM Registry. Project coordinator Clinical trial registration Q2/Q3 2.3 To identify samples from the KI cohort of Tanzania which have been analysed and samples which could be complementary analysed for HIV RNA National PI in Tanzania List of such samplesQ4 2.4 To identify samples from the KI cohort of Tanzania which could be analysed for HIV drug resistance National PI in Tanzania List of such samples Q1 2.5 To identify samples from the KI cohort of Ethiopia which have been analysed and samples which could be complementary analysed for HIV RNA National PI in Ethiopia List of such samplesQ4 WP2 Data collection

7. 7 II IMB Meeting - Addis Ababa, October 13 2011 2.6 To identify samples from the KI cohort of Ethiopia which have been analysed for HIV drug resistance and samples which could be complementary analysed National PI in Ethiopia List of such samples Q1 2.7 To identify samples from the Kenyan cohort which could be complementary analysed for HIV RNA National PI in Kenya List of such samplesQ4 2.8 To identify samples from the Kenyan cohort which could be complementary analysed for HIV drug resistance National PI in Kenya List of such samples Q1 2.9 To decide to which extent complementary HIV RNA analysis of selected samples from the Tanzanian cohort should be done National PI in Tanzania Complementary HIV RNA results in the Tanzanian part of the KI cohort Q3 2.10 To decide to which extent complementary HIV drug resistance analysis of selected samples from the Tanzanian cohort should be done National PI in Tanzania Complementary HIV drug resistance results in the Tanzanian part of the KI cohort Q1 WP2 Data collection

8. 8 II IMB Meeting - Addis Ababa, October 13 2011 2.11 To decide to which extent complementary HIV RNA analysis of selected samples from the Ethiopian cohort should be done National PI in Ethiopia Complementary HIV RNA results in the Ethiopian part of the KI cohort Q3 2.12 To decide to which extent complementary HIV drug resistance analysis of selected samples from the Ethiopian cohort should be done National PI in Ethiopia Complementary HIV drug resistance results in the Ethiopia part of the KI cohort Q1 2.13 To decide to which extent complementary HIV RNA analysis of selected samples from the Kenyan cohort should be done National PI in Kenya Complementary HIV RNA results in the Kenyan cohort Q3 2.14 To decide to which extent complementary HIV drug resistance analysis of samples from the Kenyan cohort should be done National PI in Kenya Complementary HIV drug resistance results in the Kenyan cohort Q1 2.15 Ethical review and approval for the merge of Tanzanian data to the EuResist database. (Please note that ethical approval is already existing for collecting and analysing samples) National PI in Tanzania Ethical approval in Tanzania Q1 WP2 Data collection

9. 9 II IMB Meeting - Addis Ababa, October 13 2011 WP2 Data collection 2.16 Ethical review and approval for the merge of Ethiopian data to the EuResist database. (Please note that ethical approval is already existing for collecting and analysing samples) National PI in Ethiopia Ethical approval in Ethiopia Q1 2.17 Ethical review and approval for the merge of Kenyan data to the EuResist database. (Please note that ethical approval is already existing for collecting and analysing samples) National PI in Kenya Ethical approval in Kenya Q1 2.18 Cleaning data and upload EuResist database with data from Tanzania, Ethiopia and Kenya WP2 leaderIntegrated EuResist database Q2 2.19 Retrain and evaluate the EuResist prediction engine on African data WP2 leaderEvaluation report Q4 2.20 PublicationsEach WP-leaderPublications in peer- reviewed journals Q3/4Q1/ 2 2.21 Presentations international conferences Each WP-leaderOral and/or poster presentations at international peer- reviewed conferences Q1/4Q1/ 3

10. 10 II IMB Meeting - Addis Ababa, October 13 2011 To Do WP1  Complete data management report (due May 2011)  Partnership Agreement with EuResist (due May 2011) with ethical approval (due Sept 2011)  Set next 2 telcos dates  Dissemination Plan (due Sept 2011)  Intermediate progress report (due Nov 2011)  Set next IMB meeting date

11. 11 II IMB Meeting - Addis Ababa, October 13 2011 To Do WP2  List of samples in KI cohorts in Tanzania and Ethiopia to analyse for HIV- RNA and for resistance data (due Sept 2011)  To collect HIV RNA in the 3 countries (due May 2012)  To collect resistance data in the 3 countries (due Sept 2012)

12. 12 II IMB Meeting - Addis Ababa, October 13 2011 WP3 capacity building 3. Capacity Building 3.1 Recruit trainers from Sweden and Italy National representatives List of recruited trainers Q3 3.2 Recruit trainers from Ethiopia, Tanzania and Kenya National representatives List of recruited trainers Q3 3.3 Recruit PhD/MD staff to be involved in the project National representatives List of recruited PhD/MD staff Q3 3.4 Resistance training course. Train the traineers. Nairobi. Participitants from Ethiopia, Tanzania, and Kenya Mario TotiFulfilled training course in resistance for the African traineers Q1Q1 3.5 Resistance training course. Traineers train personnel. Nairobi. Participitants from Kenya Kenyan traineeFulfilled training course in resistance for the Kenyan personnel Q4 3.6 Resistance training course. Traineers train personnel. Dar es Salaam. Participitants from Tanzania Tanzanian trainee Fulfilled training course in resistance for the Tanzanian personnel Q4 3.7 Resistance training course. Traineers train personnel. Addis Ababa. Participitants from Ethiopioa Ethiopian traineeFulfilled training course in resistance for the Ethiopian personnel Q4

13. 13 II IMB Meeting - Addis Ababa, October 13 2011 WP3 capacity building 3.8 IT/EuResist/Infcare training course. Train the traineers. Addis Ababa. Participitants from Ethiopia, Tanzania, and Kenya Maurizio ZazziFulfilled training course in IT/EuResist for the African traineers Q2Q2 3.9 IT/EuResist/Infcare training course. Traineers train personnel. All 3 countries Local trainerFulfilled training course in IT for the local personnel in the 3 countries Q1Q1 3.16 Infrastructure upgrade, RT-PCR for resistance testing, Muhumbili. Anders Sönnerborg Routines established for RT-PCR Q2Q2 3.17 Infrastructural upgrade, InfCare HIV. Dar es Salaam Anders Sönnerborg Upgrade of implemented InfCare HIV, Dar es Salaam Q3 3.18 Infrastructural upgrade; implementation open EuResist DB. Addis Ababa, Neema Mami Maurizio ZazziImplementation of open EuResist DB, Addis Ababa and Nairobi Q2Q2

14. 14 II IMB Meeting - Addis Ababa, October 13 2011 To Do WP3  Next Data management and statistics course in Dar Es Salam (Nov 2011)  Upgrade RT-PCR for resistance testing at Muhumbili (due Jan 2012)  Implementation EsaDB in Nairobi and Addis (due Jan 2012)  To set dates for IT course (due Jan 2012)  Lab training in the 3 countries to local personnel held by local trained personnel (due May 2012)

15. 15 II IMB Meeting - Addis Ababa, October 13 2011 WP4 Networking 4. Networ king 4.1 A network of partners from three African countries and three European countries will be established through the project Project Coordinator Project plan for integration of data, database management, intermittent and final results Q4Q2Q2 Q2 4.2 Joint meetings (in situ and/or TC) for project with senior scientists from KI, University of Sienna, Grosseto Hospital, Addis Ababa University, Muhumbili University and Neema Hospital Kenya Project Coordinator Join meetings with senior scientists Q3Q1Q1 Q1 4.3 Joint courses for MD/students from KI, University of Sienna, Grosseto Hospital, Addis Ababa University, Muhumbili University and Neema Hospital Kenya WP leader 4Joint courses in HIV drug resistance, use of IT tool for data management, use of InfCare HIV 4.4 EuResist prediction tool will be offered as a free support in all African countries WP leader 4Access to EuResist prediction tool including African data in African countries Q2 4.5 Communication plan to a larger public including media, Internet, seminars, policy makers EuResist consortium Communication plan Q1 4. Inclusion of African partners into the EuResist consortium according to the Partnership regulations EuResist consortium and each national representative Membership of African partners into the EuResist consortium Q3Q3

16. 16 II IMB Meeting - Addis Ababa, October 13 2011 Payment schedule Performance Related Payment Schedule Period/ Deliverable(s ) When the payments are duePercent age of grant Actual amount in Euro 1 Effective dateDate of signature by EDCTP45%127,308.60 2 First annual report 12 months + 6 weeks from effective date + approval time 24% 67,897.92 3 Second annual report 24 months + 6 weeks from effective date + approval time 21% 59,410.68 4 Final annual report 36 months+13 weeks from effective date + approval time 10% 28,290.80 Total 100%282,908.00