Functional MRI of working memory in paediatric head injury A case study Zach Holladay.

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Functional MRI of working memory in paediatric head injury A case study Zach Holladay

Introduction Subject: 8 year old boy Injury: Hit by a car Condition (fMRI): Subdural haematoma and contusion Transferred to a Rehabilitation Unit for 16 days

Methods Two assessments 15 months apart Assessment measures: Wechsler Intelligence scale, Woodcock-Johnson Test of Achievement, Child Behavioral Checklist Visuospatial working memory tasks during fMRI; 1-back and 2-back tests

Results Time 1: Lesions and atrophy in left parietal-occipital region Time 2: Atrophy in left parietal-occipital region and right parietal region Less diffuse activation in time 2 than in time 1 for 1-back tests Increased activation in time 2 for 2-back tests

Structural Imaging

Increase in correct responses for 1-back tests (78-92%) Decrease in false alarm in 1-back tests (16-6%) Increase in correct responses for 2-back tests (64-79%) Decrease in false alarm in 2-back tests (25-8%) Changes from time 1 to time 2

Discussion Cognitive performance consistent with or better than expected Differences between recovery of working memory function between developed and developing brain