LifePak® Nano Workshop North America Leadership Conference March 3, 2006 This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

One unique technology teamed with Two proprietary products drive One exclusive sponsoring story The Opportunity Simplified

Carsten R Smidt, Ph.D., FACN Vice President, Global Research & Development Pharmanex

Huzhou Mfr. Plant Shanghai R&D Center Beijing Clinical Center Provo, Utah Headquarters & Pharmanex Research Institute over 125 Scientists

Prof. Lester Packer

The Power of Nanotechnology

Nano-Switch

Nanotube Wires

What is Nanotechnology? 1.Size: nanometers –Most molecules are 1 to 100 nm in size 2.Function at the Molecular Level –Nanotechnology achieves new functionalities by molecular rearrangements

Reasons for Limited Absorption Poor intestinal solubility Requires fat for dissolution (e.g., Lipocarotenes) Aggregation into large particles –not easily digested and absorbed

The Nanotechnology Difference Pharmanex patent-pending & proprietary process Small nano-nutrients are easily dispersed and absorbed + nano-carbohydrate shell Coenzyme Q 10 nano-CoQ 10 = *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

NanoCoQ10™

NanoCoQ 10 5-fold increase in absorption! The Nanotechnology Difference

Intestinal LumenMucosa Cell (Intestinal Wall Cell) Cell Membrane nano-CoQ 10 Nano-Carbohydrate Shell CoQ 10

Nano-CoQ 10 Carotenoids? Nano-Carotenoids

lifepak ® nano Study Placebo lifepak nano ? 60+ Antioxidants Ongoing placebo-controlled clinical study

Nano- Carotenoids Nano-CoQ 10 Red Wine Polyphenols New Vitamin E Highly Effective Minerals

lifepak nano: 8 Formulas in 1 > Complete, Balanced and Convenient Multi Vitamin Mineral Anti- oxidant Formula Glucose Metabolism Formula Immune Nutrient Formula Bone Formula Cardio- Vascular Formula Anti Aging Formula

The New Dimension! For All Adults (age ) Proprietary Science Broadest Health Benefits

Angela Mastaloudis, PhD Associate Senior Scientist R&D, Pharmanex Ph.D. Exercise Physiology Oregon State University M.S. Nutrition Science Oregon State University Society for Free Radical Biology and Medicine –Young Investigator Award Lester Packer –Young Investigator Award Linus Pauling Institute –Graduate Fellowship

New, broader-spectrum nano-carotenoid formula: –alpha-carotene –beta-carotene –lycopene –lutein –zeaxanthin (new): Eye health benefits* –astaxanthin (new): Inflammatory balance* as found in 5-10 fruits & vegetables per day *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. lifepak nano

Pharmanex Nanotechnology To increase intestinal uptake of poorly absorbed fat-soluble nutrients: –Carotenoids (lycopene, alpha+beta-carotenes, zeaxanthin, astaxanthin) –Coenzyme Q 10

= Better Bioavailability* = Increased Scanner Scores* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Purpose How much more and how much faster does lifepak nano increase scanner scores than a placebo? OR PLACEBO

Study Design I Supplementation 52 Subjects were recruited and randomly assigned to groups Twice a day, with breakfast and with dinner, subjects took: –lifepak nano or –Placebo Study length: 18 weeks

Study Design II BioPhotonic Scanner Subjects were scanned a total of 15 times! Diet We encouraged to continue with their typical diet for the entire study

Results 42 out of 52 subjects completed the 18 week study

* * * * * * * * * Scanner Scores Increase with lifepak nano *p<0.05 between groups 45% Increase! 41% Increase! 37% Increase! 30% Increase! 19% Increase!

Scanner Scores Increase with lifepak nano *p<0.05 compared to wk 0 #p<0.05 compared to placebo #, * NSEGlobal Convention Convention

Scanner Scores Increase with lifepak nano *p<0.05 compared to wk 0 #p<0.05 compared to placebo #, *

Summary Lifepak nano increased scanner scores as fast as two weeks Scanner scores increased in all 20 subjects taking lifepak nano Lifepak nano increased scanner scores 18,000 units more than placebo in 18 weeks Even after 18 weeks scanner scores were still increasing in the lifepak nano group

Better Bioavailability* Faster and Higher Increases in Scanner Scores* = *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Power of Nanotechnology Visit our PRODUCT SHOWCASE!

Key Business Takeaways Nanotechnology increases absorption of poorly absorbed nutrients* First in industry to apply nanotechnology to a multivitamin supplement* Proprietary and patent-pending Guaranteed to increase SCS* Clinically proven ~ 18,000 increase Do You NANO? *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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