1. The Role of Cortisol in Health & Longevity
Presented by William Kraemer, Ph.D.
Professor of Kinesiology
University of Connecticut
This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

2. What is Cortisol? Cortisol is the body’s primary stress hormone
“Fight-or-Flight” response
Regulates inflammation, carbohydrate metabolism, cardiovascular function, etc…
BUT too much cortisol for too long leads to health concerns

3. Normal Diurnal Cortisol Rhythm

4. Cortisol Response to Stress
Epel et al. Psychosom Med 2000;62(5):623-32

5. Trier Social Stress Test
(public speaking & arithmetic)
M. Altemus, Cornell University.

6. Cortitrol™ STRESS CONTROL FORMULA
Supports healthy cortisol levels*
Presented by Shawn Talbott, Ph.D.
Director, Scientific Affairs
Pharmanex, LLC
This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

7. What is Cortisol? Cortisol is the body’s primary stress hormone
“Fight-or-Flight” response
Required by the body for survival
Regulates carbohydrate metabolism, cardiovascular function, etc…
BUT too much cortisol for too long leads to problems
Repeated exposure to stressful situations (personal, family, work)
Modern stressors do not permit fight or flight
Stress hormones may not dissipate
Stress leads to health consequences

8. Stanford stress researcher
Robert Sapolsky, PhD
Stanford stress researcher

9. Cortitrol™ Helps Control Cortisol to Cope with Stress

10. Cortisol Levels Are Elevated In...
Stressful situations
Sleep deprivation
Dieting / Restrained eating
Adults who need to control cortisol levels are…
Frequently confronted with stressful situations
Getting less than 8 hours of sleep every night
Generally feel run down, lack mental focus
Limiting caloric intake to lose weight

11. Stress and the Workplace
Psychological demands at work that exceed one’s capacity to cope produce a variety of physiological responses that, over time, lead to health concerns.
Work demands and low level of job control lead to changes in cortisol levels.
Ganster et al. Journal of Applied Psychology, 2001, 86,

12. Cortisol in the Media
More Than 1,000 News Articles Over the Past Year!
Time, Washington Post, Men’s Health, Prevention, Glamour, Shape, Woman’s World, Reader’s Digest, Reuters, ABC, MSNBC…
1st International Symposium on Cortisol, Stress and Health
May Experts from United States, Canada, and Europe gathered in Park City, Utah presented emerging research related to cortisol
New Book: The Cortisol Connection
Published September 2002

13. The Solution: Cortisol Management
You can control cortisol levels via:
Stress Management Techniques
meditation, coping strategies, etc…
Exercise
Pharmanex Body Design
Nutrition
Dietary Supplements*
LifePak™ + Cortitrol™ STRESS CONTROL FORMULA
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

14. Common Anti-Stress Solutions
Valerian
Kava Kava
Melatonin
Tyrosine
None of these supplements directly address cortisol control

15. Cortitrol™ STRESS CONTROL FORMULA - Health Benefits -
Enhances feelings of wellbeing and control in response to stressful situations*
Improves performance and increased vigor throughout the day*
Better mental concentration and focus*
Supports weight maintenance efforts*
Hint… CORTITROL for CORTIsol conTROL
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

16. Proprietary Stress Control Formula
Comprehensive formula addresses both direct cortisol modulation and stress control
Scientifically-validated ingredients in clinically significant dosages
Magnolia Bark (2% Honokiol), Ashwagandha, Passion Flower
Epimedium (6:1 water extract), Garlic
L-Theanine (70:1 all-natural extract)
Phosphatidylserine
Beta-sitosterol

17. Scientific Substantiation
Magnolia Bark
anti-stress effects; non-sedating
Epimedium
reduces cortisol levels during high stress; promotes energy levels
L-Theanine
increase alpha brain wave production; promotes relaxed alertness and concentration; non-sedating
Phosphatidylserine
reduces cortisol levels following strenuous exercise; improves mental function
Beta-sitosterol
balances cortisol:DHEA ratio; supports immune function
*References available from Pharmanex, LLC

18. Competitive Advantage
First patent-pending dietary supplement that supports healthy cortisol levels*
Proprietary blend + Comprehensive Approach
Modulates cortisol levels
Helps combat stress
Improves mental function
Contains a proprietary, all-natural form of theanine extracted from green tea leaves
Manufactured according to the Pharmanex® 6S® Quality Process
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

19. Recommended Usage Combine with LifePak® Family
Everyone should use Cortitrol!
Frequently confronted with stressful situations
Getting less than 8 hours of sleep every night
Generally feel run down, lack mental focus
Limiting caloric intake to lose weight
Combine with LifePak® Family
Vitamin C, B vitamins, calcium, magnesium
Directions for Use Take 2 capsules with your evening meal. For optimal results take an additional (1) capsule with your morning meal.

20. www.pharmanex.com Pharmanex Information Packet product information
powerpoint presentation (What’s New)
Pharmanex Information Packet
product fact sheet
frequently asked questions
Pharmanex Product Showcase
meet the experts
interactive computer product training