Membrane Membrane receptors. Single-pass membrane receptors membrane.

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Presentation transcript:

membrane Membrane receptors

Single-pass membrane receptors membrane

Multi-pass membrane receptors

Ion channel membrane receptors membrane + +

Ion channel membrane receptors

Receptor kinases

Kinase activities associated with receptors intrinsic tyrosine kinase activity JAK tyrosine kinase activity

G-protein-linked receptors GTP hormone membrane

G-protein-linked receptors    GDP

G-protein-linked receptors   adapter adenylate cyclase 

Insulin activation of glucose response IRS-1 P P PP P P GLUT

Follicle Stimulating Hormone & Receptor

FSH subunit mRNAs Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

FSH subunit polypeptides Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

FSH Fox, et al. Mol Endocrinol (2001) 15:

FSH Receptor Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481 mRNA

FSH Receptor Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

FSH Receptor (C, cysteine; S, serine; K, lysine; R, arginine; N, asparagine; A, alanine; D, aspartic acid; F, phenylalanine). Mann, et al. (2000) Biol. Reprod. 62:

FSH Receptor Mann, et al. (2000) Biol. Reprod. 62:

FSH Receptor Sohn, et al. (2003) J. Biol. Chem. 278: –47876

FSH Receptor Sohn, et al. (2003) J. Biol. Chem. 278: –47876

FSH Receptor Gay et al. (2006) Nature Reviews Immunology 6:

Natural mutations of FSH & Receptor Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481