2. Amino Acids Metabolism Amino Acids Metabolism 2 nd Year Medicine By Eman Mokbel Alissa, Ph.D.

3. Lecture (1) content Relationship to central metabolism Nitrogen disposal 1.Transamination (aminotransferases/ transaminases) 2.Glutamate dehydrogenase (amino acid oxidative deamination) 3.Oxidative and nonoxidative deamination Ammonia transport to liver 1.Glutamine cycle 2.Glucose- Alanine cycle

4. Lecture (2) content Urea Cycle –Urea Cycle importance and regulation –Metabolic Disorders of Urea Cycle Sources and Fates of Ammonia Transport of ammonia in the circulation Hyperammonemia Toxicity To Brain

5. Lecture (3) content Amino Acid Metabolic Classification Catabolism of C skeleton of amino acids Fate of C skeleton Synthesis and Degradation of amino acids Amino Acid Biological Classification Non-essential amino acids synthesis Metabolism of individual amino acids: –Glycine

6. Lecture (4) Content Metabolism of individual amino acids: –Branched chain amino acids –Arginine –Proline –Lysine –Serine –Histidine

7. Lecture (5) Content Metabolism of individual amino acids: –Phenylalanine –Tyrosine –Tryptophan

8. Lecture (6) Content Metabolism of individual amino acids: –Aspartate –Aspargine –Glutamate –Glutamine –Alanine –β-alanine Metabolism of individual amino acids: –Cysteine –Methionine S-adenosyl methionine