© 2003, Wellsource Inc. Effect of Ketogenic Diet on Lipid Levels (shown is LDL-C) In this group of 141 children followed for 6 months, a ketogenic diet adversely affected blood lipid levels: –Cholesterol +58 mg/dL –LDL chol +50 mg/dL (2 SD) –HDL chol –7 mg/dL –Triglycerides +58 mg/dL LDL Cholesterol (mg/dL) JAMA 290:912-20, Aug 20, 2003

© 2003, Wellsource Inc. Effect of Ketogenic Diet on HDL Cholesterol HDL cholesterol levels dropped 7 mg/dL HDL Cholesterol (mg/dL) JAMA 290:912-20, Aug 20, 2003

© 2003, Wellsource Inc. Effect of Ketogenic Diet on Triglyceride Levels Triglyceride levels rose by 58 mg/dL Triglyceride (mg/dL) JAMA 290:912-20, Aug 20, 2003

© 2003, Wellsource Inc. Effect of Ketogenic Diet on LDL Cholesterol Levels At baseline, 75% of the children were low risk (LDL <170) After 6 months, 53% were high risk (LDL 130+) and only 28% were in the low risk category Study population (%) JAMA 290:912-20, Aug 20, 2003

© 2003, Wellsource Inc. Effect of Ketogenic Diet on HDL Cholesterol Levels At baseline, 75% of the children were low risk (HDL >45) After 6 months, only 51% were low risk and 16% were in the high risk category (HDL <35) Study population (%) JAMA 290:912-20, Aug 20, 2003