1. Slide Source: Lipids Online Slide Library www.lipidsonline.org LDL Cholesterol, mg/dL Years of Follow-up Ridker PM et al. N Engl J Med 2002;347:1557–1565. Copyright, ©2002 Massachusetts Medical Society. Event-Free Survival by Baseline Quintiles of CRP and LDL-C: Women's Health Study C-Reactive Protein, mg/L Probability of Event-free Survival (0.49) (0.50–1.08) (1.09–2.09) (2.10–4.19) (>4.19) (97.6) (97.7–115.4) (115.4–132.2) (132.3–153.9) (>153.9) 1.00 0.99 0.98 0.97 0.96 0.00 1.00 0.99 0.98 0.97 0.96 0.00 0246802468 1st 2nd 3rd 4th 5th Quintile 1st 2nd 3rd 4th 5th Quintile

2. Slide Source: Lipids Online Slide Library www.lipidsonline.org Relative Risk for a First CV Event by Baseline CRP Quintile: Women's Health Study RR (95% CI) p Area under ROC CRP quintile12345 mg/L 0.49 0.50–1.08 1.09–2.09 2.10–4.19 >4.19 Crude1.01.8 (1.1–2.7) 2.3 (1.5–3.4) 3.2 (2.2–4.8) 4.5 (3.1–6.6) <.0010.64 Age-adjusted1.01.5 (1.0–2.4) 1.8 (1.2–2.8) 2.5 (1.7–3.7) 3.6 (2.5–5.2) <.0010.74 RF-adjusted* 1.01.4 (0.9–2.2) 1.6 (1.1–2.4) 2.0 (1.3–3.0) 2.3 (1.6–3.4) <.0010.81 All models adjusted for treatment assignment. *Risk factors: age, smoking status, diabetes, blood pressure, HRT Ridker PM et al. N Engl J Med 2002;347:1557–1565. Copyright, ©2002 Massachusetts Medical Society.

3. Slide Source: Lipids Online Slide Library www.lipidsonline.org Relative Risk for a First CV Event by Baseline LDL-C Quintile: Women's Health Study All models adjusted for treatment assignment. *Risk factors: age, smoking status, diabetes, blood pressure, HRT RR (95% CI) p Area under ROC LDL-C quintile 12345 mg/dL 97.6 97.7–115.4 115.5–132.2 132.3–153.9 >153.9 Crude1.01.0 (0.8–1.4) 1.3 (1.0–1.8) 1.8 (1.4–2.4) 2.2 (1.7–2.9) <.0010.60 Age- adjusted 1.00.9 (0.7–1.3) 1.1 (0.9–1.5) 1.5 (1.1–1.9) 1.7 (1.3–2.2) <.0010.73 RF*- adjusted 1.00.9 (0.7–1.2) 1.1 (0.8–1.4) 1.3 (1.0–1.7) 1.5 (1.1–2.0) <.0010.81 Ridker PM et al. N Engl J Med 2002;347:1557–1565. Copyright, ©2002 Massachusetts Medical Society.

4. Slide Source: Lipids Online Slide Library www.lipidsonline.org Multivariable-Adjusted Relative Risk CRP < median, LDL < median 1.0 1.5 (1.0–2.1) Ridker PM et al. N Engl J Med 2002;347:1557–1565. Multivariable-Adjusted Relative Risk for First CV Event by CRP and LDL-C above or below the Median: WHS CRP median CRP > median, LDL < median CRP > median, LDL > median 1.5 (1.1–2.1) 2.1 (1.5–2.8) Median CRP 1.52 mg/L; Median LDL-C 123.7 mg/dL

5. Slide Source: Lipids Online Slide Library www.lipidsonline.org Multivariable Relative Risk Framingham Estimate of 10-yr Risk, % 0–12–45–9 10 Ridker PM et al. N Engl J Med 2002;347:1557–1565. Multivariable-Adjusted Relative Risk for First CV Event by CRP and Framingham Risk Score and by CRP and LDL-C Categories: WHS LDL-C, mg/dL <130130–160>160 <1.0 1.0–3.0 >3.0