1. © 2004, Wellsource Inc. Low Carbohydrate Diet and LDL Cholesterol Levels 119 men and women, 24 weeks On the low carb diet, LDL increased slightly On low calorie diet, LDL dropped 7 points LDL Cholesterol Levels Annals of Internal Medicine, May 18, 2004 LDL Cholesterol mg/dL

2. © 2004, Wellsource Inc. Low Carb vs Conventional Diet 0 6 12 Months Weight loss, kg n=132 Annals of Internal Medicine, May 18, 2004

3. © 2004, Wellsource Inc. One Year Changes in Groups Low carb diet Conv diet Weight loss-11 lb -7 lb Calorie intake1662 1822 LDL chol, mg/dL112 to 120 121 to 118 HDL chol, mg/dL41 to 40 41 to 36 Glucose, mg/dL100 to 103 99 to 102 Annals of Internal Medicine, May 18, 2004

4. © 2004, Wellsource Inc. Researcher’s Summary We found no significant difference in overall weight loss between persons on these two diets at one year. Our data suggest that weight loss differences may be explained by lower caloric intake on a low carbohydrate diet. Annals of Internal Medicine, May 18, 2004

5. © 2004, Wellsource Inc. Researcher’s Summary The HDL cholesterol level decreased more in the conventional diet than in the low carbohydrate diet by one year. The difference in the response of glucose and insulin sensitivity between diet groups by 1 year was not significant. Annals of Internal Medicine, May 18, 2004

6. © 2004, Wellsource Inc. Researcher’s Conclusions Restriction of carbohydrate in obese persons, who may be over consuming carbohydrate at baseline, may have a favorable metabolic effect. Annals of Internal Medicine, May 18, 2004