Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Report of he MGSD Nutrition Study B. Karamanos MD Associate Professor of Medicine.

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Presentation transcript:

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Report of he MGSD Nutrition Study B. Karamanos MD Associate Professor of Medicine 10 th Meeting of the MGSD 27 April 2007 Istambul

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS year mortality % in the 7 Country Study AreaN All cause CHD Non CHD Non Mediter ranean Mediter ranean Keys et al Am J Epidemiol 124:903, 1986

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Diet and 15 year mortality 7 – country study SAFAPositivePUFANull MUFANegativeProteinNull MUFA/SAFANegativeCHONull Keys et al Am J Epidem 124:903, 1986

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Change in Mortality after a two point increment in the Mediterranean Diet Score MortalityHRCI Total – 0.87 CVD – 0.94 Cancer – 0.98 NEJM 348:2599, 2003

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Fat intake g/day in Nicotera, Italy Males67117 Females51119

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Comparison of the Dietary Questionnaire with the 3-Day Diet Diary Questionnairep3-Day Diet Diary Energy Kcal/day 1897NS1791 CHO g/day Prot g/day83NS80 Fat g/day79NS81

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Comparison of the Dietary Questionnaire with the 3-Day Diet Diary Questionnairep3-Day Diet Diary Animal Fat35NS35 Plant Fat41NS43 Cholesterol263NS263 Fibre g/day

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Subjects studied 4254 MalesFemalesTotal Normals Diabetics Total

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Obesity % in males and females without and with Diabetes AlgEgyI-PavI-RomGrBulgSerb M 7.5% F 6.1% M F norm DM

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Conclusions The prevalence of obesity varies greatly among Mediterranean countries In diabetics does not reach the 80% reported in the literature

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Energy intake and % contribution of each nutrient to it (normals) AlgEgyI-PavI-RomGrBulg Energy Protein% Fat% CHO%

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Conclusions The prevalence of obesity varies greatly among Mediterranean countries In diabetics does not reach the 80% reported in the literature Diet composition varies greatly among countries

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 MGSD NormalDiabetic Kcal/day2654*1897 CHO %47.9*44.0 Fat %32.8*34.6 Prot %16.0*19.3 Fiber g/d22.2NS21.9

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Percentage of subjects who meet the Nutritional Recommendations of the DNSG. (normal & diabetic) AlgEgyI-PavI-RomGrBulgSerb Prot, CHO and Fat N DM All above and Fibre N DM

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Mediterranean Diet Comparison of data from the 7 – country and MGSD studies. Greece BreadPotatoVegetFruitMeatCheeseMilk Kromhout D. Am J Clin Nutr 49:889, Karamanos B. Eur J Clin Nutr 56:983, 2002

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Mediterranean Diet Score Plant /Animal Fat ratio Vegetables Alcohol ConsumptionMeat Legumes Dairy products Cereals Fruits Fish Score 0-9 Good > 5 BMJ 311: , 1995

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 MGSD g/dNormalDiabetic Bread219 * 170 Fish3234 Fruit325 * 266 Meat Vegetables185 * 252 % Recomm3225 % MedDiet5836

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Conclusions The prevalence of obesity varies greatly among Mediterranean countries In diabetics does not reach the 80% reported in the literature Diet composition varies greatly among countries Nutritional recommendations and MD are followed by very few subjects, especially in diabetics

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Fat intake and Diabetes MGSD Study Unknown DMControls Fat %34.7 *30.4 Animal Fat % 14.2 **10.6 Thanopulou A. Diabetes Care 26:302, %34.0%

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Conclusions The prevalence of obesity varies greatly among Mediterranean countries In diabetics does not reach the 80% reported in the literature Diet composition varies greatly among countries Nutritional recommendations and MD are followed by very few subjects, especially in diabetics Fat intake is related with the incidence of diabetes

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Prevalence of the Metabolic Syndrome by country and in the population as a whole

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Prevalence of the Metabolic Syndrome by BMI category p<0,001

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Prevalence of the Metabolic Syndrome in the Mediterranean countries Observed (499 subjects) Expected (441 subjects) % p= % OR=1.18 (CI )

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Metabolic Syndrome (NCEP-ATP III) Presence  3 of the following risk factors Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. JAMA. 2001;285: Risk factorLevel Central Obesity Waist circumference Males Females >102 cm > 88 cm Triglycerides  150 mg% HDL-C Males Females <40 mg/dL <50 mg/dL Blood Pressure  130 /  85 mm Hg Fasting Glucose  110 mg%

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 DM2NORp W * HDL * BP30.1%14.2%1.8<0.001 Tg * HDL* BP27.9%27.9%11.7%2.3<0.001 W * Tg * BP23.3%7.2%2.8<0.001 W * Tg * HDL21.0%7.2%5.9<0.001 W * Tg * HDL * BP 17.6%5.2%3.9<0.001

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007 Conclusions The prevalence of obesity varies greatly among Mediterranean countries In diabetics does not reach the 80% reported in the literature Diet composition varies greatly among countries Nutritional recommendations are followed by very few subjects, especially in diabetics Fat intake is related with the incidence of diabetes The components of MetS cluster more frequently than expected by chance Diabetes per se promotes the clustering of the other 4 components of MetS

Diabetes Centre Hippokration Hospital Athens, Greece B. KARAMANOS 2007