1. Metabolic Syndrome in Non-Diabetics Vilanova Fillat, M.B. Falguera Vilamajó, M. Garriga Badia, A. Miró Vallvé, N. Cebrian Aiguadé, C. Escardó Font, C Bacompte Jorba, C Vivas Solé, S. Solé Llop, G. Bertran Rodríguez, M

2. The prevalence of Metabolic Syndrome (MS) among Spanish adults of working age is about 12% Registro MESYAS The prevalence of MS in United States is a 23% Ford, JAMA 2002 Most patients (> 80%) with type 2 diabetes have MS, but the opposite is not necessarily true. Metabolic Syndrome (MS) increases the risk of developing type 2 diabetes and cardiovascular diseases

3. THEORY The prevalence of Metabolic Syndrome in non-diabetics is thought to be lower than in the general population

4. To determine the prevalence of Metabolic Syndrome in non-diabetics PURPOSE

5. METHODS Cross-sectional study Subjects aged ≥ 18 years Ramdomly selected from a region (population ≈37.267) Cross-sectional study Subjects aged ≥ 18 years Ramdomly selected from a region (population ≈37.267) Exclusion criteria: Diabetes Gestational diabetes Secondary diabetes A1C ≥ 5.7% Variables recorded: Age Gender Waist circumference Blood pressure Drugs treatment Metabolic syndrome defined according the National Cholesterol Education Program Adult Treatment Pannel III 2001 (NCEP ATP III) Variables recorded: Fasting plasma glucose HDL cholesterol Triglycerides A1C

6. NCEP ATP III 2001 Blood Pressure≥ 130/85 mmHg or drugs Fasting Plasma Glucose≥ 110 mg/dL or drugs Hypertriglyceridaemia≥ 150 mg/dL Low HDL-cholesterol< 40 mg/dL in males < 50 mg/dL in females Central obesityWaist circumference > 88 cm females > 102 cm males

7. RESULTS N=282 subjects Average age 51.4 years (95% CI 49.9-52.9) 61.7% women 38.3% men Average A1C: 5.64 (95% CI 5.59-5.69)

8. RESULTS N=282 subjects Average95% CI Waist circumference (cm)94.593.1-95.8 Sistolic blood pressure (mmHg)122.5120.6-124.4 Diastolic blood pressure (mmHg)77.476.3-78.6 Fasting plasma glucose (mg/dl)94.693.8-95.4 HDL cholesterol (mg/dl)62.460.5-64.3 Triglycerides (mg/dl)102.095.1-108.9 The prevalence of MS was 17.8% (95% CI 13.8-21.8) The prevalence of MS was 17.8% (95% CI 13.8-21.8)

9.  The prevalence of Metabolic Syndrome in the general population is about 17-24%.  In our research, it is about 18%, excluding diabetes.  Our study suggests that Metabolic Syndrome is associated with diabetes, but this is not a determining factor.  The other components (high blood pressure, hypertriglyceridaemia, low HDL cholesterol and central obesity) have an important role in the development of that condition.  Improving the control of these risk factors could reduce the risk of developing cardiovacular diseases. DISCUSSION

10. Thank you for your attention!