Smallpox Divya Raj

History 3,000 years ago- Africa, Asia, Europe New World- 1400s-1500s

Variola (major/ minor) Orthopoxvirus, Poxiviridae Brick Linear double-stranded DNA

Smallpox Types Variola Vaccinia Cowpox Monkeypox

Transmission Airborne Bodily Fluids Contagious

Symptoms Fever Malaise Headache Fatigue Back Pain Vomiting, Diarrhea Rash- Spots, Blisters

Vs. Chickenpox Severity- Superficial Location- Trunk Type- Stage of lesions Timing- Contagiousness

4 Types Ordinary- 90%, unvaccinated Modified- vaccinated Malignant- 5-10%, children Hemorrhagic- 2%, adults

Prognosis 30% overall 50-75% ordinary- confluent 25-30% ordinary- semi-confluent 90%- Flat 100%- Hemorrhagic 1%- Minor

Complications Scars % Blindness- 2-5%

Treatment None Supportive Inoculation/ Variolation

Vaccine Edward Jenner 1796 Cowpox Side Effects

Eradication 1979 Atlanta, Koltsovo Destruction

Biological warfare Lack of vaccination

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